Empirical Evidence for Son-Killing X Chromosomes and the Operation of SA-Zygotic Drive 英文参考文献.docVIP
- 1、本文档共8页,可阅读全部内容。
- 2、原创力文档(book118)网站文档一经付费(服务费),不意味着购买了该文档的版权,仅供个人/单位学习、研究之用,不得用于商业用途,未经授权,严禁复制、发行、汇编、翻译或者网络传播等,侵权必究。
- 3、本站所有内容均由合作方或网友上传,本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺!文档内容仅供研究参考,付费前请自行鉴别。如您付费,意味着您自己接受本站规则且自行承担风险,本站不退款、不进行额外附加服务;查看《如何避免下载的几个坑》。如果您已付费下载过本站文档,您可以点击 这里二次下载。
- 4、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等,请点击“版权申诉”(推荐),也可以打举报电话:400-050-0827(电话支持时间:9:00-18:30)。
- 5、该文档为VIP文档,如果想要下载,成为VIP会员后,下载免费。
- 6、成为VIP后,下载本文档将扣除1次下载权益。下载后,不支持退款、换文档。如有疑问请联系我们。
- 7、成为VIP后,您将拥有八大权益,权益包括:VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
- 8、VIP文档为合作方或网友上传,每下载1次, 网站将根据用户上传文档的质量评分、类型等,对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档
查看更多
Empirical Evidence for Son-Killing X Chromosomes and the Operation of SA-Zygotic Drive 英文参考文献
EmpiricalEvidenceforSon-KillingXChromosomesand
theOperationofSA-ZygoticDrive
UrbanFriberg1,2*,AndrewD.Stewart1,WilliamR.Rice1
1Department of Ecology, Evolution and Marine Biology, University of California Santa Barbara, Santa Barbara, California, United States of America, 2Department of
EvolutionaryBiology,UppsalaUniversity,Uppsala,Sweden
Abstract
Background:Diploidorganismshavetwocopiesofallgenes,butonlyoneiscarriedbyeachhaploidgameteanddiploid
offspring. This causes a fundamental genetic conflict over transmission rate between alternative alleles. Single genes, or
gene clusters, only rarely code for the complex phenotypes needed to give them a transmission advantage (drive
phenotype).However,allgenesonamale’sXandYchromosomesco-segregate,allowingdifferentsex-linkedgenestocode
for different parts of the drive phenotype. Correspondingly, the well-characterized phenomenon of male gametic drive,
occurring during haploid gametogenesis, is especially common on sex chromosomes. The new theory of sexually
antagonisticzygoticdriveofthesexchromosomes(SA-zygoticdrive)extendsthelogicofgameticdriveintothediploid
phaseofthelifecycle,wheneverthereiscompetitionamongsiblingsorharmfulsib-sibmating.TheXandYarepredictedto
gainatransmissionadvantagebyharmingoffspringofthesexthatdoesnotcarrythem.
Results: Here weanalyzed amutant X-chromosome in Drosophila simulans that produced an excess of daughters when
transmittedfrommales.WedevelopedaseriesofteststodifferentiatebetweengameticandSA-zygoticdrive,andprovide
multiplelinesofevidencethatSA-zygoticdriveisresponsibleforthesexratiobias.Drivingsiresproduceabout50%more
survivingdaughtersthansons.
Conclusion: Sex-ratio distortion due to genetic conflict has evolved via gametic drive and maternally transmitted
endosymbionts.Ourdataindicatethatsexchromosomescanalsodrivebyharmingthenon-carriersexofoffspring.
Citation:FribergU,StewartAD,RiceWR(2011)EmpiricalEvidenceforSon-KillingXChromosomesandtheOperationofSA-ZygoticDrive.PLoSONE6(8):e23508.
doi
您可能关注的文档
- Elevated Antigen-Driven IL-9 Responses Are Prominent in Peanut Allergic Humans 英文参考文献.doc
- Elephant (Loxodonta africana) Home Ranges in Sabi Sand Reserve and Kruger National Park A Five-Year Satellite Tracking Study 英文参考文献.doc
- Elevated Expression of KiSS-1 in Placenta of Chinese Women with Early-Onset Preeclampsia 英文参考文献.doc
- Elevated Bile Acids in Newborns with Biliary Atresia (BA) 英文参考文献.doc
- Elevated Cardiac Troponin I in Sepsis and Septic Shock No Evidence for Thrombus Associated Myocardial Necrosis 英文参考文献.doc
- Elevated Glutamatergic Compounds in Pregenual Anterior Cingulate in Pediatric Autism Spectrum Disorder Demonstrated by 1H MRS and 1H MRSI 英文参考文献.doc
- Elevated Hemostasis Markers after Pneumonia Increases One-Year Risk of All-Cause and Cardiovascular Deaths 英文参考文献.doc
- Electrotonic Signals along Intracellular Membranes May Interconnect Dendritic Spines and Nucleus 英文参考文献.doc
- Elevated Homocysteine by Levodopa Is Detrimental to Neurogenesis in Parkinsonian Model 英文参考文献.doc
- Elevated IKKα Accelerates the Differentiation of Human Neuronal Progenitor Cells and Induces MeCP2-Dependent BDNF Expression 英文参考文献.doc
文档评论(0)