Epistasis Analysis for Estrogen Metabolic and Signaling Pathway Genes on Young Ischemic Stroke Patients 英文参考文献.docVIP

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Epistasis Analysis for Estrogen Metabolic and Signaling Pathway Genes on Young Ischemic Stroke Patients 英文参考文献.doc

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Epistasis Analysis for Estrogen Metabolic and Signaling Pathway Genes on Young Ischemic Stroke Patients 英文参考文献

EpistasisAnalysisforEstrogenMetabolicandSignaling PathwayGenesonYoungIschemicStrokePatients Yi-ChenHsieh1,Jiann-ShingJeng2,Huey-JuanLin3,Chaur-JongHu4,Chia-ChenYu1,Li-MingLien5 ,Giia- SheunPeng6,Chin-IChen7,Sung-ChunTang2,Nai-FangChi4,Hung-PinTseng8,Chang-MingChern9,10, Fang-IHsieh1,Chyi-HueyBai1,Yi-RhuChen1,Hung-YiChiou1,11*,fortheFormosaStrokeGenetic Consortium(FSGC) 1SchoolofPublicHealth,TaipeiMedicalUniversity,Taipei,Taiwan,2StrokeCenterandDepartmentofNeurology,NationalTaiwanUniversityHospital,Taipei,Taiwan, 3Department of Neurology, Chi-Mei Medical Center, Tainan, Taiwan, 4Department of Neurology, Taipei Medical University Hospital and Shuang Ho Hospital, Taipei, Taiwan,5DepartmentofNeurology,ShinKongWuHo-SuMemorialHospital,Taipei,Taiwan,6DepartmentofNeurology,Tri-ServiceGeneralHospital,Taipei,Taiwan, 7DepartmentofNeurology,WanfangHospital,TaipeiMedicalUniversity,Taipei,Taiwan,8DepartmentofNeurology,LotungPoh-AiHospital,I-Lan,Taiwan,9Department ofNeurology,TaipeiVeteransGeneralHospital,Taipei,Taiwan,10DepartmentofMedicine,SchoolofMedicine,NationalYang-MingUniversity,Taipei,Taiwan,11Dr.Chi- HsingHuangStrokeResearchCenter,TaipeiMedicalUniversity,Taipei,Taiwan Abstract Background:Endogenousestrogensplayanimportantroleintheoverallcardiocirculatorysystem.However,thereareno studies exploring the hormone metabolism and signaling pathway genes together on ischemic stroke, including sulfotransferasefamily1E(SULT1E1),catechol-O-methyl-transferase(COMT),andestrogenreceptora(ESR1). Methods: A case-control study was conducted on 305 young ischemic stroke subjects aged 50 years and 309 age- matched healthy controls. SULT1E1 -64G/A, COMT Val158Met, ESR1 c.4542397 T/C and c.4542351 A/G genes were genotyped and compared between cases and controls to identify single nucleotide polymorphisms associated with ischemicstrokesusceptibility.Gene-geneinteractioneffectswereanalyzedusingentropy-basedmultifactordimensionality reduction(MDR),classificationandregressiontree(CART),andtradi