Establishing a Cohort at High Risk of HIV Infection in South Africa Challenges and Experiences of the CAPRISA 002 Acute Infection Study 英文参考文献.docVIP
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Establishing a Cohort at High Risk of HIV Infection in South Africa Challenges and Experiences of the CAPRISA 002 Acute Infection Study 英文参考文献
EstablishingaCohortatHighRiskofHIVInfectionin
SouthAfrica:ChallengesandExperiencesoftheCAPRISA
002AcuteInfectionStudy
FrancoisvanLoggerenberg1*,KolekaMlisana1,CarolynWilliamson1,2,SaraC.Auld1,3,LynnMorris1,4
,
CliveM.Gray1,4,QuarraishaAbdoolKarim1,3,AnnekeGrobler1,NomampondoBarnabas1,ItuaIriogbe1,
SalimS.AbdoolKarim1,3 fortheCAPRISA002AcuteInfectionStudyTeam
1Centre for the AIDS Programme of Research in South Africa (CAPRISA), University of KwaZulu-Natal, Durban, South Africa, 2Institute for of Infectious Disease and
MolecularMedicine,UniversityofCapeTown,CapeTown,SouthAfrica,3ColumbiaUniversity,NewYork,NewYork,UnitedStatesofAmerica,4NationalInstitutefor
CommunicableDiseases,Johannesburg,SouthAfrica
Abstract
Objectives:Todescribethebaselinedemographicdata,clinicalcharacteristicsandHIV-incidenceratesofacohortathigh
riskforHIVinfectioninSouthAfricaaswellasthechallengesexperiencedinestablishingandmaintainingthecohort.
Methodology/PrincipleFindings:BetweenAugust2004andMay2005acohortofHIV-uninfectedwomenwasestablished
fortheCAPRISA002AcuteInfectionStudy,anaturalhistorystudyofHIV-1subtypeCinfection.Volunteerswereidentified
throughpeer-outreach.ThecohortwasfollowedmonthlytodetermineHIVinfectionratesandclinicalpresentationofearly
HIVinfection.Riskreductioncounsellingandmaleandfemalecondomswereprovided.Afterscreening775individuals,a
cohortof245uninfectedhigh-riskwomenwasestablished.HIV-prevalenceatscreeningwas59.6%(95%CI:55.9%to62.8%)
posingachallengeinaccruingHIV-uninfectedwomen.Themajorityofwomen(78.8%)wereself-identifiedassex-workers
with a median of 2 clients per day. Most women (95%) reported more than one casual sexual partner in the previous
3months(excludingclients)and58.8%reportedcondomuseintheirlastsexualencounter.Basedonlaboratorytesting,
62.0%hadasexuallytransmittedinfectionatbaseline.During390person-yearsoffollow-up,28infectionsoccurredyielding
seroincidence rate of 7.2 (95% CI: 4.5 to 9.8) per 100 person-years. Despite the high mobility of this sex worker co
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