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Establishing Zebrafish as a Novel Exercise Model Swimming Economy, Swimming-Enhanced Growth and Muscle Growth Marker Gene Expression 英文参考文献.docVIP

Establishing Zebrafish as a Novel Exercise Model Swimming Economy, Swimming-Enhanced Growth and Muscle Growth Marker Gene Expression 英文参考文献.doc

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Establishing Zebrafish as a Novel Exercise Model Swimming Economy, Swimming-Enhanced Growth and Muscle Growth Marker Gene Expression 英文参考文献

EstablishingZebrafishasaNovelExerciseModel: SwimmingEconomy,Swimming-EnhancedGrowthand MuscleGrowthMarkerGeneExpression ArjanP.Palstra1,2*.,ChristianTudorache2.,MireiaRovira1,SebastiaanA.Brittijn2,ErikBurgerhout2, GuidoE.E.J.M.vandenThillart2,HermanP.Spaink2,JosepV.Planas1 1Departament de Fisiologia, Facultat de Biologia, Institut de Biomedicina de la Universitat de Barcelona (IBUB), Universitat de Barcelona, Barcelona, Spain, 2Sylvius Laboratory,MolecularCellBiology,InstituteofBiology,LeidenUniversity(IBL),Leiden,TheNetherlands Abstract Background:Zebrafishhasbeenlargelyacceptedasavertebratemultidisciplinarymodelbutitsusefulnessasamodelfor exercisephysiologyhasbeenhamperedbythescarceknowledgeonitsswimmingeconomy,optimalswimmingspeeds and cost of transport. Therefore, we have performed individual and group-wise swimming experiments to quantify swimmingeconomyandtodemonstratetheexerciseeffectsongrowthinadultzebrafish. Methodology/Principal Findings: Individual zebrafish (n=10) were able to swim at a critical swimming speed (Ucrit ) of 0.54860.007m s21 or 18.0 standard body lengths (BL) s21. The optimal swimming speed (Uopt) at which energetic efficiencyishighestwas0.39660.019ms21(13.0BLs21)correspondingto72.2660.29%ofUcrit.Thecostoftransportat optimalswimmingspeed(COTopt)was25.2364.03mmolg21m21.Agroup-wiseexperimentwasconductedwithzebrafish (n=83)swimmingatUoptfor6hday21for5daysweek21for4weeksvs.zebrafish(n=84)thatrestedduringthisperiod. Swimmingzebrafishincreasedtheirtotalbodylengthby5.6%andbodyweightby41.1%ascomparedtorestingfish.For thefirsttime,ahighlysignificantexercise-inducedgrowthisdemonstratedinadultzebrafish.Expressionanalysisofasetof musclegrowthmarkergenesrevealedclearregulatoryrolesinrelationtoswimming-enhancedgrowthforgenessuchas growthhormonereceptorb(ghrb),insulin-likegrowthfactor1receptora(igf1ra),troponinC(stnnc),slowmyosinheavy chain1(smyhc1),troponinI2(tnni2),myosinheavypolypeptide2(myhz2)andmyostatin(mstnb). Conclusions/Significance:Fromtheresu

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