Estimation of the Total Parasite Biomass in Acute Falciparum Malaria from Plasma PfHRP2 英文参考文献.docVIP

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Estimation of the Total Parasite Biomass in Acute Falciparum Malaria from Plasma PfHRP2 英文参考文献.doc

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Estimation of the Total Parasite Biomass in Acute Falciparum Malaria from Plasma PfHRP2 英文参考文献

o Openaccess,freelyavailableonline PL S MEDICINE EstimationoftheTotalParasiteBiomass inAcuteFalciparumMalariafromPlasma PfHRP2 ArjenM.Dondorp1,2,VaruneeDesakorn1,WirichadaPongtavornpinyo1,DuangjaiSahassananda1,KamolratSilamut1, KesineeChotivanich1,PaulN.Newton2,3,PunneePitisuttithum1,A.M.Smithyman4,NicholasJ.White1,2*,NicholasP.J.Day1,2 1FacultyofTropicalMedicine,MahidolUniversity,Bangkok,Thailand,2CentreforClinicalVaccinologyandTropicalMedicine,ChurchillHospital,Oxford,UnitedKingdom, 3WellcomeTrust–MahosotHospital,Vientiane,LaoPeople’sDemocraticRepublic,4Cellabs,Brookvale,NewSouthWales,Australia CompetingInterests:Theauthors havedeclaredthatnocompeting interestsexist. ABSTRACT Background AuthorContributions:AMDand NJWdesignedthestudy.AMDand PNNenrolledthepatients.VD,DS, KS,KC,PP,andAMScontributedto thelaboratorystudies.AMD,WP, andNPJDanalyzedthedata.All authorscontributedtowritingthe paper. InfalciparummalariasequestrationoferythrocytescontainingmatureformsofPlasmodium falciparuminthemicrovasculatureofvitalorgansiscentraltopathology,butquantitationof thishiddensequesteredparasiteloadinvivohasnotpreviouslybeenpossible.Theperipheral blood parasite count measures only the circulating, relatively non-pathogenic parasite numbers. P. falciparum releases a specific histidine-rich protein (PfHRP2) into plasma. Quantitative measurement of plasma PfHRP2 concentrations may reflect the total parasite biomassinfalciparummalaria. AcademicEditor:SanjeevKrishna,St. George’sHospitalMedicalSchool, UnitedKingdom MethodsandFindings Citation:DondorpAM,DesakornV, PongtavornpinyoW,Sahassananda D,SilamutK,etal.(2005)Estimation ofthetotalparasitebiomassinacute falciparummalariafromplasma PfHRP2.PLoSMed2(8):e204. We measured plasma concentrations of PfHRP2, using a quantitative antigen-capture enzyme-linkedimmunosorbentassay,in337adultpatientswithfalciparummalariaofvarying severity hospitalised on the Thai–Burmese border. Based on in vitro production rates, we constructed a model to