Evaluation of the Efficacy and Cross-Protectivity of Recent Human and Swine Vaccines against the Pandemic (H1N1) 2009 Virus Infection 英文参考文献.docVIP

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Evaluation of the Efficacy and Cross-Protectivity of Recent Human and Swine Vaccines against the Pandemic (H1N1) 2009 Virus Infection 英文参考文献.doc

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Evaluation of the Efficacy and Cross-Protectivity of Recent Human and Swine Vaccines against the Pandemic (H1N1) 2009 Virus Infection 英文参考文献

EvaluationoftheEfficacyandCross-Protectivityof RecentHumanandSwineVaccinesagainstthePandemic (H1N1)2009VirusInfection PhilippeNorielQ.Pascua1,Min-SukSong1,JunHanLee1,KukJinPark1,Hyeok-ilKwon1,YunHeeBaek1, Seung-PyoHong2,Jong-BokRho2,Chul-JoongKim3,HaryoungPoo4,ThomasS.Ryoo5 ,Moon-Hee Sung2,YoungKiChoi1* 1CollegeofMedicineandMedicalResearchInstitute,ChungbukNationalUniversity,Cheongju,RepublicofKorea,2BioleadersCorporation,Daejeon,RepublicofKorea, 3College of Veterinary Medicine, Chungnam National University, DaeJeon, Republic of Korea, 4Korean Research Institute of Bioscience and Biotechnology, Daejeon, RepublicofKorea,5PrestigeWorldGenetics,GeneticsKorea,Ltd.,Pyongtaek,RepublicofKorea Abstract Thecurrentpandemic(H1N1)2009virusremainstransmissibleamonghumansworldwidewithcasesofreversezoonosis, providing opportunities to produce more pathogenic variants which could pose greater human health concerns. To investigatewhetherrecentseasonalhumanorswineH1N1vaccinescouldinducecross-reactiveimmuneresponsesagainst infectionwiththepandemic(H1N1)2009virus,mice,ferretsormini-pigswereadministeredwithvariousregimens(onceor twice)andantigencontent(1.77,3.5or7.5mgHA)ofa-Brsibane/59/07,a-CAN01/04orRgCA/04/09xPR8vaccine.Receiptof a-CAN01/04(2-doses)butnota-Brisbane/59/07induceddetectablebutmodest(20–40units)cross-reactiveserumantibody againstCA/04/09byhemagglutinininhibition(HI)assaysinmice.Onlydoubleadministration(7.5mgHA)ofbothvaccinein ferretscouldelicitcross-reactivity(30–60HItiters).Similarantigencontentofa-CAN01/04inmini-pigsalsocausedamodest ,30HItiters(twicevaccinated).However,vaccine-inducedantibodytiterscouldnotsuppressactivevirusreplicationinthe lungs(mice)orvirusshedding(ferretsandpigs)ofimmunizedhostsintranasallychallengedwithCA/04/09.Furthermore, neither ferrets nor swine could abrogate aerosol transmission of the virus into na?¨ve contact animals. Altogether, these results suggest that neither recent human nor animal H1N1 vaccine could provide complete protectivity in