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Exogenous Addition of a C-Xylopyranoside Derivative Stimulates Keratinocyte Dermatan Sulfate Synthesis and Promotes Migration 英文参考文献.docVIP

Exogenous Addition of a C-Xylopyranoside Derivative Stimulates Keratinocyte Dermatan Sulfate Synthesis and Promotes Migration 英文参考文献.doc

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Exogenous Addition of a C-Xylopyranoside Derivative Stimulates Keratinocyte Dermatan Sulfate Synthesis and Promotes Migration 英文参考文献

ExogenousAdditionofaC-XylopyranosideDerivative StimulatesKeratinocyteDermatanSulfateSynthesisand PromotesMigration JunMuto1,NanditaNatashaNaidu2,KenshiYamasaki1,NathaliePineau3,LionelBreton3.,RichardL. Gallo1*. 1Division of Dermatology, University of California, San Diego and Veterans Affairs San Diego Health Care System, San Diego, California, United States of America, 2GlycotechnologyCoreResource,UniversityofCalifornia,SanDiego,California,UnitedStatesofAmerica,3L’Orea′lRecherche,Clichy,France Abstract AsC-Xylosidehasbeensuggestedtobeaninitiatorofglycosaminoglycan(GAG)synthesis,andGAGssuchasDermatan sulfate (DS) are potent enhancers of fibroblast growth factor (FGF) - 10 action, we investigated if a C-Xylopyranoside derivative,(C-b-D-xylopyranoside-2-hydroxy-propane,C-Xyloside),couldpromoteDSproductionbyculturednormalhuman keratinocytes, how this occurs and if C-Xyloside could also stimulate FGF-dependent cell migration and proliferation. C- Xyloside-treated keratinocytes greatly increased secretion of total sulfated GAGs. Majority of the induced GAG was chondroitin sulfate/dermatan sulfate (CS/DS) of which the major secreted GAG was DS. Cells lacking xylosyltransferase enzymatic activity demonstrated that C-Xyloside was able tostimulate GAG synthesis without addition to core proteins. ConsistentwiththeobservedincreaseinDS,keratinocytestreatedwithC-Xylosideshowedenhancedmigrationinresponse toFGF-10andsecretedintotheirculturemediaGAGsthatpromotedFGF-10-dependentcellularproliferation.Theseresults indicatethatC-XylosidemayenhanceepithelialrepairbyservingasaninitiatorofDSsynthesis. Citation:MutoJ,NaiduNN,YamasakiK,PineauN,BretonL,etal.(2011)ExogenousAdditionofaC-XylopyranosideDerivativeStimulatesKeratinocyteDermatan SulfateSynthesisandPromotesMigration.PLoSONE6(10):e25480.doi:10.1371/journal.pone.0025480 Editor:Ju¨rgenSchauber,Ludwig-Maximilian-University,Germany ReceivedAugust26,2011;AcceptedSeptember5,2011;PublishedOctober5,2011 Thisisanopen-accessarticle,freeofall

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