Exogenous Addition of a C-Xylopyranoside Derivative Stimulates Keratinocyte Dermatan Sulfate Synthesis and Promotes Migration 英文参考文献.docVIP
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Exogenous Addition of a C-Xylopyranoside Derivative Stimulates Keratinocyte Dermatan Sulfate Synthesis and Promotes Migration 英文参考文献
ExogenousAdditionofaC-XylopyranosideDerivative
StimulatesKeratinocyteDermatanSulfateSynthesisand
PromotesMigration
JunMuto1,NanditaNatashaNaidu2,KenshiYamasaki1,NathaliePineau3,LionelBreton3.,RichardL.
Gallo1*.
1Division of Dermatology, University of California, San Diego and Veterans Affairs San Diego Health Care System, San Diego, California, United States of America,
2GlycotechnologyCoreResource,UniversityofCalifornia,SanDiego,California,UnitedStatesofAmerica,3L’Orea′lRecherche,Clichy,France
Abstract
AsC-Xylosidehasbeensuggestedtobeaninitiatorofglycosaminoglycan(GAG)synthesis,andGAGssuchasDermatan
sulfate (DS) are potent enhancers of fibroblast growth factor (FGF) - 10 action, we investigated if a C-Xylopyranoside
derivative,(C-b-D-xylopyranoside-2-hydroxy-propane,C-Xyloside),couldpromoteDSproductionbyculturednormalhuman
keratinocytes, how this occurs and if C-Xyloside could also stimulate FGF-dependent cell migration and proliferation. C-
Xyloside-treated keratinocytes greatly increased secretion of total sulfated GAGs. Majority of the induced GAG was
chondroitin sulfate/dermatan sulfate (CS/DS) of which the major secreted GAG was DS. Cells lacking xylosyltransferase
enzymatic activity demonstrated that C-Xyloside was able tostimulate GAG synthesis without addition to core proteins.
ConsistentwiththeobservedincreaseinDS,keratinocytestreatedwithC-Xylosideshowedenhancedmigrationinresponse
toFGF-10andsecretedintotheirculturemediaGAGsthatpromotedFGF-10-dependentcellularproliferation.Theseresults
indicatethatC-XylosidemayenhanceepithelialrepairbyservingasaninitiatorofDSsynthesis.
Citation:MutoJ,NaiduNN,YamasakiK,PineauN,BretonL,etal.(2011)ExogenousAdditionofaC-XylopyranosideDerivativeStimulatesKeratinocyteDermatan
SulfateSynthesisandPromotesMigration.PLoSONE6(10):e25480.doi:10.1371/journal.pone.0025480
Editor:Ju¨rgenSchauber,Ludwig-Maximilian-University,Germany
ReceivedAugust26,2011;AcceptedSeptember5,2011;PublishedOctober5,2011
Thisisanopen-accessarticle,freeofall
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