Expression of HLA Class I and HLA Class II by Tumor Cells in Chinese Classical Hodgkin Lymphoma Patients 英文参考文献.docVIP

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Expression of HLA Class I and HLA Class II by Tumor Cells in Chinese Classical Hodgkin Lymphoma Patients 英文参考文献.doc

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Expression of HLA Class I and HLA Class II by Tumor Cells in Chinese Classical Hodgkin Lymphoma Patients 英文参考文献

ExpressionofHLAClassIandHLAClassIIbyTumorCells inChineseClassicalHodgkinLymphomaPatients XinHuang1,2,AnkevandenBerg1,ZifenGao2,LydiaVisser1,IljaNolte3,HansVos1,BoukeHepkema4, WierdKooistra1,SibrandPoppema1,ArjanDiepstra1* 1DepartmentofPathologyandMedicalBiology,UniversityMedicalCenterGroningen,UniversityofGroningen,Groningen,TheNetherlands,2DepartmentofPathology, Health Science Center, Peking University, Beijing, China, 3Unit of Genetic Epidemiology and Bioinformatics, Department of Epidemiology, University Medical Center Groningen,UniversityofGroningen,Groningen,TheNetherlands,4DepartmentofLaboratoryMedicine,UniversityMedicalCenterGroningen,UniversityofGroningen, Groningen,TheNetherlands Abstract Background: InCaucasianpopulations,thetumorcellsofEpsteinBarrvirus(EBV)-positiveclassicalHodgkinLymphomas (cHL)patientsmorefrequentlyexpressHLAclassIandHLAclassIImoleculescomparedtoEBV-negativecHLpatients.HLA expression(inrelationtoEBV)inAsiancHLpatientshasnotbeenpreviouslyinvestigated. Methodology/Principal Findings: We randomly selected 145 cHL patients with formalin-fixed, paraffin embedded tissue blocksavailablefrom5hospitalsfromtheNorthernpartofChina.HematoxylinEosin-stainedslideswereusedtoreclassify thehistologicalsubtypesaccordingtotheWHOclassification.EBVstatuswasdeterminedbyvisualizationofEBERsintumor cellsusinginsituhybridization.MembranousexpressionofHLAmoleculeswasdetectedbyimmunohistochemistryusing antibodiesHC-10(classIheavychain)andanti-?2-microglobulinforHLAclassI,andCR3/43forHLAclassII.EBV+tumorcells wereobservedin40%(58/145)ofthecHLpatients.Asexpected,thepercentageofEBV+caseswasmuchhigherinthe mixed cellularity subtype (71%) than in the nodular sclerosis subtype (16%) (p,0.001). Expression of HLA class I was observedin79%oftheEBV+cHLcasesandin30%oftheEBV-cases(p,0.001).ForHLAclassII,52%ofEBV+cHLcases werepositive,comparedto43%inEBV-cases(p=0.28). Conclusions:TheresultsintheNorthernChinapopulationweresimilartothoseintheCaucasianpopulationforHLAclassI, bu