Exosomes Communicate Protective Messages during Oxidative Stress; Possible Role of Exosomal Shuttle RNA 英文参考文献.docVIP

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Exosomes Communicate Protective Messages during Oxidative Stress; Possible Role of Exosomal Shuttle RNA 英文参考文献.doc

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Exosomes Communicate Protective Messages during Oxidative Stress; Possible Role of Exosomal Shuttle RNA 英文参考文献

ExosomesCommunicateProtectiveMessagesduring OxidativeStress;PossibleRoleofExosomalShuttleRNA MariaEldh1,KarinEkstro¨m1,HadiValadi2,MargaretaSjo¨strand1,BobOlsson3,MargaretaJerna?s3 ,Jan Lo¨tvall1* 1Krefting Research Centre, Dept. of Internal Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, 2Department of Rheumatology and InflammationResearch,SahlgrenskaAcademy,UniversityofGothenburg,Gothenburg,Sweden,3DepartmentofInternalMedicine,SahlgrenskaAcademy,Universityof Gothenburg,Gothenburg,Sweden Abstract Background:Exosomesaresmallextracellularnanovesiclesofendocyticoriginthatmediatedifferentsignalsbetweencells, by surface interactions and by shuttling functional RNA from one cell to another. Exosomes are released by many cells includingmastcells,dendriticcells,macrophages,epithelialcellsandtumourcells.Exosomesdiffercomparedtotheirdonor cells,notonlyinsize,butalsointheirRNA,proteinandlipidcomposition. Methodology/PrincipalFindings:Inthisstudy,weshowthatexosomes,releasedbymousemastcellsexposedtooxidative stress, differ in their mRNA content. Also, we show that these exosomes can influence the response of other cells to oxidativestressbyprovidingrecipientcellswitharesistanceagainstoxidativestress,observedasanattenuatedlossofcell viability.Furthermore,AffymetrixmicroarrayanalysisrevealedthattheexosomalmRNAcontentnotonlydiffersbetween exosomesanddonorcells,butalsobetweenexosomesderivedfromcellsgrownunderdifferentconditions;oxidativestress and normal conditions. Finally, we also show that exposure to UV-light affects the biological functions associated with exosomesreleasedunderoxidativestress. Conclusions/Significance:TheseresultsarguethattheexosomalshuttleofRNAisinvolvedincell-to-cellcommunication, byinfluencingtheresponseofrecipientcellstoanexternalstressstimulus. Citation:EldhM,Ekstro¨mK,ValadiH,Sjo¨strandM,OlssonB,etal.(2010)ExosomesCommunicateProtectiveMessagesduringOxidativeStress;PossibleRoleof ExosomalShuttleRNA.PLoSONE5(12):e15353.doi:10