Evolutionarily Conserved Substrate Substructures for Automated Annotation of Enzyme Superfamilies 英文参考文献.docVIP
- 1、本文档共11页,可阅读全部内容。
- 2、原创力文档(book118)网站文档一经付费(服务费),不意味着购买了该文档的版权,仅供个人/单位学习、研究之用,不得用于商业用途,未经授权,严禁复制、发行、汇编、翻译或者网络传播等,侵权必究。
- 3、本站所有内容均由合作方或网友上传,本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺!文档内容仅供研究参考,付费前请自行鉴别。如您付费,意味着您自己接受本站规则且自行承担风险,本站不退款、不进行额外附加服务;查看《如何避免下载的几个坑》。如果您已付费下载过本站文档,您可以点击 这里二次下载。
- 4、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等,请点击“版权申诉”(推荐),也可以打举报电话:400-050-0827(电话支持时间:9:00-18:30)。
- 5、该文档为VIP文档,如果想要下载,成为VIP会员后,下载免费。
- 6、成为VIP后,下载本文档将扣除1次下载权益。下载后,不支持退款、换文档。如有疑问请联系我们。
- 7、成为VIP后,您将拥有八大权益,权益包括:VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
- 8、VIP文档为合作方或网友上传,每下载1次, 网站将根据用户上传文档的质量评分、类型等,对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档
查看更多
Evolutionarily Conserved Substrate Substructures for Automated Annotation of Enzyme Superfamilies 英文参考文献
EvolutionarilyConservedSubstrateSubstructuresfor
AutomatedAnnotationofEnzymeSuperfamilies
RanyeeA.Chiang,AndrejSali,PatriciaC.Babbitt*
DepartmentsofBiopharmaceuticalSciencesandPharmaceuticalChemistryandCaliforniaInstituteforQuantitativeBiosciences,UniversityofCaliforniaatSanFrancisco,
SanFrancisco,California,UnitedStatesofAmerica
Abstract
Theevolutionofenzymesaffectshowwellaspeciescanadapttonewenvironmentalconditions.Duringenzymeevolution,
certainaspectsofmolecularfunctionareconservedwhileotheraspectscanvary.Aspectsoffunctionthataremoredifficult
tochangeorthatneedtobereusedinmultiplecontextsareoftenconserved,whilethosethatvarymayindicatefunctions
thataremoreeasilychangedorthatarenolongerrequired.Inanalogytothestudyofconservationpatternsinenzyme
sequencesandstructures,wehaveexaminedthepatternsofconservationandvariationinenzymefunctionbyanalyzing
graph isomorphisms among enzyme substrates of a large number of enzyme superfamilies. This systematic analysis of
substrate substructures establishes the conservation patterns that typify individual superfamilies. Specifically, we
determined the chemical substructures that are conserved among all known substrates of a superfamily and the
substructures that are reacting in these substrates and then examined the relationship between the two. Across the 42
superfamiliesthatwereanalyzed,substantialvariationwasfoundinhowmuchoftheconservedsubstructureisreacting,
suggestingthatsuperfamiliesmaynotbeeasilygroupedintodiscreteandseparablecategories.Instead,ourresultssuggest
that many superfamilies may need to be treated individually for analyses of evolution, function prediction, and guiding
enzymeengineeringstrategies.Annotatingsuperfamilieswiththeseconservedandreactingsubstructurepatternsprovides
informationthatisorthogonaltoinformationprovidedbystudiesofconservationinsuperfamilysequencesandstructures,
thereby improving the precision with which we can predict the functions of enzymes of unknown function and direct
studies in enzyme
您可能关注的文档
- Evidence for Direct Involvement of the Capsid Protein in HIV Infection of Nondividing Cells 英文参考文献.doc
- Evidence for Gene-Specific Rather Than Transcription Rate–Dependent Histone H3 Exchange in Yeast Coding Regions 英文参考文献.doc
- Evidence for Pervasive Adaptive Protein Evolution in Wild Mice 英文参考文献.doc
- Evidence for Polymicrobic Flora Translocating in Peripheral Blood of HIV-Infected Patients with Poor Immune Response to Antiretroviral Therapy 英文参考文献.doc
- Evidence for Positive Selection in Putative Virulence Factors within the Paracoccidioides brasiliensis Species Complex 英文参考文献.doc
- Evidence for Positive Selection on the Osteogenin (BMP3) Gene in Human Populations 英文参考文献.doc
- Evidence for Positive Selection on the Leptin Gene in Cetacea and Pinnipedia 英文参考文献.doc
- Evidence for Mitochondrial Respiratory Deficiency in Rat Rhabdomyosarcoma Cells 英文参考文献.doc
- Evidence for Oxidative Stress and Defective Antioxidant Response in Guinea Pigs with Tuberculosis 英文参考文献.doc
- Evidence for Positive Selection on a Number of MicroRNA Regulatory Interactions during Recent Human Evolution 英文参考文献.doc
最近下载
- 生殖系统彩色图解.ppt
- 2023年变频器投资申请报告.docx VIP
- uapv63-1主子表单据操作手册预订单ver.1.pdf VIP
- 新高考数学解题研究——高考题型全归纳.pdf
- uap63攻略4课件1ria平台uapv63-ria单据开发.pdf VIP
- 应急器材使用及维护培训.pptx
- 中医科带状疱疹诊疗规范、诊疗路径.pdf
- 四川省成都市天府新区2023-2024学年七年级下学期语文期末考试试卷.docx VIP
- 2.3地域文化与城乡景观(课件)高一地理(人教版2019必修第二册).pptx
- 2.2地域文化与城乡景观 课件 2023-2024学年高一年级地理中图版(2019)必修第二册.pptx VIP
文档评论(0)