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Fatal Disseminated Cryptococcus gattii Infection in New Mexico 英文参考文献
FatalDisseminatedCryptococcusgattiiInfectioninNew
Mexico
CarlaJ.Walraven1,2,WendyGerstein1,2,SarahE.Hardison3,FloydWormley3,ShawnR.Lockhart4,JulieR.
Harris4,AnnetteFothergill5,BrianWickes5,JulieGober-Wilcox1,LarryMassie1,T.S.NeilKu1,2 ,Carolina
Firacative6,WielandMeyer6,SamuelA.Lee1,2*
1Section of Infectious Diseases, New Mexico Veterans Healthcare System, Albuquerque, New Mexico, United States of America, 2Division of Infectious Diseases,
University of New Mexico Health Science Center, Albuquerque, New Mexico, United States of America, 3Department of Biology, South Texas Center for Emerging
InfectiousDiseases,TheUniversityofTexasatSanAntonio,SanAntonio,Texas,UnitedStatesofAmerica, 4MycoticDiseasesBranch,CentersforDiseaseControland
Prevention,Atlanta,Georgia,UnitedStatesofAmerica,5DepartmentofMicrobiologyandImmunology,UniversityofTexasHealthScienceCenter,SanAntonio,Texas,
UnitedStatesofAmerica,6MolecularMycologyResearchLaboratory,CentreforInfectiousDiseasesandMicrobiology,WestmeadMillenniumInstitute,SydneyMedical
School-WestmeadHospital,TheUniversityofSydney,NewSouthWales,Australia
Abstract
WereportacaseoffataldisseminatedinfectionwithCryptococcusgattiiinapatientfromNewMexico.Thepatienthadno
historyofrecenttraveltoknownC.gattii-endemicareas.Multilocussequencetypingrevealedthattheisolatebelongedto
themajormoleculartypeVGIII.Virulencestudiesinamousepulmonarymodelofinfectiondemonstratedthatthestrain
waslessvirulentthanotherC.gattiistrains.ThisrepresentsthefirstdocumentedcaseofC.gattiilikelyacquiredinNew
Mexico.
Citation: Walraven CJ, Gerstein W, Hardison SE, Wormley F, Lockhart SR, et al. (2011) Fatal Disseminated Cryptococcus gattii Infection in New Mexico. PLoS
ONE6(12):e28625.doi:10.1371/journal.pone.0028625
Editor:JoySturtevant,LouisianaStateUniversity,UnitedStatesofAmerica
ReceivedJuly14,2011;AcceptedNovember11,2011;PublishedDecember14,2011
Thisisanopen-accessarticle,freeofallcopyright,andmaybefreelyreproduced,distributed,transmitted,modified,builtupon,o
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