Favorable Changes in Lipid Profile The Effects of Fasting after Ramadan 英文参考文献.docVIP

FavorableChangesinLipidProfile:TheEffectsofFasting afterRamadan AbdullahShehab1*,AbdishakurAbdulle1,AwadElIssa1,JassimAlSuwaidi2,NicoNagelkerke3 1DepartmentofInternalMedicine,FacultyofMedicineandHealthSciences,UAEUniversity,Al-Ain,UnitedArabEmirates,2DepartmentofCardiologyandCardiovascular Surgery, Hamad General Hospital, Doha, Qatar, 3Department of Community Medicine, Faculty of Medicine and Health Sciences, UAE University, Al-Ain, United Arab Emirates Abstract Aims:WeassessedtheeffectoffastingduringRamadanonbloodpressure(BP),bodyweight,plasmalipid,andlipoprotein variablesamonghealthynormalindividuals. Methods: 102 (68%male)multi-ethnic volunteers; meanage 6 SD (38.7610.5years) wererandomly recruitedin Al-Ain, UnitedArabEmirates(UAE),tobeinvestigatedbeforeRamadan,onedayaftertheendofRamadan,andfourweeksafter Ramadan. Anthropometric, demographic, fasting plasma total cholesterol (TC), triglyceride (TG), and high density lipoprotein–cholesterol(HDL-C)weremeasuredbystandardmethods,andLowdensitylipoprotein-cholesterol(LDL-C)was calculatedusingFriedewald’sformula. Results: 65 subjects completed the study. We found significant and beneficial changes in systolic blood pressure (SBP), bodyweight,waistcircumference(WC),TG,HDL-CandLDL-C,attheendofRamadan,butnotinTC.Further,therewasa progressiveandsignificantincreaseanddecreaseinHDL-CandLDL-Clevels,respectively,fourweeksafterRamadan. Conclusions: We observed significant improvements in HDL-C, and LDL-C levels even after four weeks post Ramadan. Ramadan-likefastingmaybeconsideredformoreeffectivelipidandlipoproteincontrol. Citation: Shehab A, Abdulle A, El Issa A, Al Suwaidi J, Nagelkerke N (2012) Favorable Changes in Lipid Profile: The Effects of Fasting after Ramadan. PLoS ONE7(10):e47615.doi:10.1371/journal.pone.0047615 Editor:VladimirN.Uversky,UniversityofSouthFloridaCollegeofMedicine,UnitedStatesofAmerica ReceivedJune29,2012;AcceptedSeptember19,2012;PublishedOctober24,2012 Copyright: ? 2012 Shehab et al. This is an open-a