Gene Expression Study of MonocytesMacrophages during Early Foreign Body Reaction and Identification of Potential Precursors of Myofibroblasts 英文参考文献.docVIP

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Gene Expression Study of MonocytesMacrophages during Early Foreign Body Reaction and Identification of Potential Precursors of Myofibroblasts 英文参考文献.doc

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Gene Expression Study of MonocytesMacrophages during Early Foreign Body Reaction and Identification of Potential Precursors of Myofibroblasts 英文参考文献

GeneExpressionStudyofMonocytes/Macrophages duringEarlyForeignBodyReactionandIdentificationof PotentialPrecursorsofMyofibroblasts LindsayMesure.,GeofreyDeVisscher*.,IlseVranken,AnLebacq,WillemFlameng LaboratoryofExperimentalCardiacSurgery,DepartmentofCardiovascularDiseases,KULeuven,Leuven,Belgium Abstract Foreign body reaction (FBR), initiated by adherence of macrophages to biomaterials, is associated with several complications. Searching for mechanisms potentially useful to overcome these complications, we have established the signaling role of monocytes/macrophages in the development of FBR and the presence of CD34 cells that potentially + + differentiateintomyofibroblasts.Therefore,CD68 cellswereinvitroactivatedwithfibrinogenandalsopurifiedfromthe FBR after 3 days of implantation in rats. Gene expression profiles showed a switch from monocytes and macrophages attracted by fibrinogen to activated macrophages and eventually wound-healing macrophages. The immature FBR also contained a subpopulation of CD34+ cells, which could be differentiated into myofibroblasts. This study showed that macrophagesarethecleardrivingforceofFBR,dependentonmilieu,andmyofibroblastdepositionanddifferentiation. Citation:MesureL,DeVisscherG,VrankenI,LebacqA,FlamengW(2010)GeneExpressionStudyofMonocytes/MacrophagesduringEarlyForeignBodyReaction andIdentificationofPotentialPrecursorsofMyofibroblasts.PLoSONE5(9):e12949.doi:10.1371/journal.pone.0012949 Editor:RaquelGonc?alves, UniversidadedoPorto,Portugal ReceivedApril30,2010;AcceptedAugust16,2010;PublishedSeptember23,2010 Copyright: ? 2010 Mesure et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalauthorandsourcearecredited. Funding: This project was partially funded by the National Fund for Scientific Research (Fonds voor Wetenschappelijk Onderzoek-Vlaanderen); Grant No.G.0549.06. Additional fu