Genetic and Molecular Basis of Individual Differences in Human Umami Taste Perception 英文参考文献.docVIP

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Genetic and Molecular Basis of Individual Differences in Human Umami Taste Perception 英文参考文献.doc

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Genetic and Molecular Basis of Individual Differences in Human Umami Taste Perception 英文参考文献

GeneticandMolecularBasisofIndividualDifferencesin HumanUmamiTastePerception NoriatsuShigemura*,ShinyaShirosaki,KeisukeSanematsu,RyusukeYoshida,YuzoNinomiya SectionofOralNeuroscience,GraduateSchoolofDentalScience,KyushuUniversity,Fukuoka,Japan Abstract Umamitaste(correspondstosavoryinEnglish)iselicitedbyL-glutamate,typicallyasitsNasalt(monosodiumglutamate: MSG),andisoneoffivebasictastequalitiesthatplaysakeyroleinintakeofaminoacids.Aparticularpropertyofumamiis thesynergisticpotentiationofglutamatebypurinenucleotidemonophosphates(IMP,GMP).AheterodimerofaGprotein coupled receptor, TAS1R1 and TAS1R3, is proposed to function as its receptor. However, little is known about genetic variationofTAS1R1andTAS1R3anditspotentiallinkswithindividualdifferencesinumamisensitivity.Hereweinvestigated theassociationbetweenrecognitionthresholdsforumamisubstancesandgeneticvariationsinhumanTAS1R1andTAS1R3, andthefunctionsofTAS1R1/TAS1R3variantsusingaheterologousexpressionsystem.Ourstudydemonstratedthatthe TAS1R1-372Tcreatesamoresensitiveumamireceptorthan-372A,whileTAS1R3-757Ccreatesalesssensitiveonethan- 757RforMSGandMSGplusIMP,andshowedastrongcorrelationbetweentherecognitionthresholdsandinvitrodose- responserelationships.TheseresultsinhumanstudiessupportthepropositionsthataTAS1R1/TAS1R3heterodimeractsas anumamireceptor,andthatgeneticvariationinthisheterodimerdirectlyaffectsumamitastesensitivity. Citation:ShigemuraN,ShirosakiS,SanematsuK,YoshidaR,NinomiyaY(2009)GeneticandMolecularBasisofIndividualDifferencesinHumanUmamiTaste Perception.PLoSONE4(8):e6717.doi:10.1371/journal.pone.0006717 Editor:HiroakiMatsunami,DukeUnviersity,UnitedStatesofAmerica ReceivedMay10,2009;AcceptedJuly23,2009;PublishedAugust21,2009 Copyright: ?2009 Shigemura et al. This isanopen-accessarticle distributedunder the terms of the Creative Commons Attribution License, which permits unrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalauthorandsourcearecredited. Funding: This work was supported by