High Incidence of Multiple Viral Infections Identified in Upper Respiratory Tract Infected Children under Three Years of Age in Shanghai, China 英文参考文献.docVIP

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High Incidence of Multiple Viral Infections Identified in Upper Respiratory Tract Infected Children under Three Years of Age in Shanghai, China 英文参考文献.doc

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High Incidence of Multiple Viral Infections Identified in Upper Respiratory Tract Infected Children under Three Years of Age in Shanghai, China 英文参考文献

HighIncidenceofMultipleViralInfectionsIdentifiedin UpperRespiratoryTractInfectedChildrenunderThree YearsofAgeinShanghai,China GuocuiZhang1,2,YunwenHu1,HongpingWang1,LuZhang1,YixiBao2,XiaomingZhou1* 1ShanghaiPublicHealthClinicalCenter,AffiliatedtoFudanUniversity,Shanghai,China,2DepartmentofClinicalLaboratory,SecondAffiliatedHospitalofChongqing MedicalUniversity,Chongqing,China Abstract Background:Upperrespiratorytractinfection(URTI)isamajorreasonforhospitalizationinchildhood.Morethan80%of URTIsareviral.EtiologicaldiagnosisofURTIsisimportanttomakecorrectclinicaldecisionsontreatmentmethods.However, dataforviralspectrumofURTIsareverylimitedinShanghaichildren. Methods:Nasopharyngealswabswerecollectedfromagroupof164childrenagedbelow3yearswhowerehospitalized due to acute respiratory infection from May 2009 to July 2010 in Shanghai. A VRDAL multiplex PCR for 10 common respiratory viruses was performed on collected specimens compared with the SeeplexH RV15 ACE Detection kit for 15 respiratoryviruses. Results:Virusesweredetectedin84(51.2%)patientsbyVRDALmultiplexPCR,and8(4.9%)ofcasesweremixedinfections. Using the SeeplexH RV15 ACE Detection kit, viruses were detected in 129 (78.7%) patients, 49 (29.9%) were co-infected cases. Identified viruses included 37 of human rhinovirus (22.6% of cases), 32 of influenza A virus (19.5%), 30 of parainfluenzavirus-2 (18.3%), 23 of parainfluenzavirus-3 (14.0%), 15 of human enterovirus (9.1%), 14 each of parainfluenzavirus-1, respiratory syncytial virus B and adenovirus (8.5%), 8 of coronavirus 229E/NL63 (4.9%), 6 of human bocavirus(3.7%),5eachofinfluenzaBvirusandrespiratorysyncytialvirusA(3.0%),3ofparainfluenzavirus-4(1.8%),2of coronavirusOC43/HKU1(1.2%),and1humanmetapneumovirus(0.6%). Conclusions: A high frequency of respiratory infections (78.7%) and co-infections (29.9%) was detected in children with acute respiratory infection symptoms in Shanghai. The SeeplexH RV15 ACE detection method was found to be a more reliablehighthroughpu