Hepcidin Is Involved in Iron Regulation in the Ischemic Brain 英文参考文献.docVIP

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Hepcidin Is Involved in Iron Regulation in the Ischemic Brain 英文参考文献.doc

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Hepcidin Is Involved in Iron Regulation in the Ischemic Brain 英文参考文献

HepcidinIsInvolvedinIronRegulationintheIschemic Brain HuiDing1.,Cai-ZhenYan1,2.,HonglianShi3,Ya-ShuoZhao1,Shi-YangChang1,PengYu1 ,Wen-Shuang Wu1,Chen-YangZhao1,Yan-ZhongChang1*,Xiang-LinDuan1* 1Laboratory of Molecular Iron Metabolism, College of Life Science, Hebei Normal University, Shijiazhuang, China, 2Department of Pharmacology, Hebei Medical University,Shijiazhuang,China,3DepartmentofPharmacologyandToxicology,SchoolofPharmacy,UniversityofKansas,Lawrence,Kansas,UnitedStatesofAmerica Abstract Oxidativestressplaysanimportantroleinneuronalinjuriescausedbycerebralischemia.Itiswellestablishedthatfreeiron increasessignificantlyduringischemiaandisresponsibleforoxidativedamageinthebrain.However,themechanismofthis ischemia-inducedincreaseinironisnotcompletelyunderstood.Inthisreport,themiddlecerebralarteryocclusion(MCAO) rat model was performed and the mechanism of iron accumulation in cerebral ischemia-reperfusion was studied. The expressionofL-ferritinwassignificantlyincreasedinthecerebralcortex,hippocampus,andstriatumontheischemicside, whereasH-ferritinwasreducedinthestriatumandincreasedinthecerebralcortexandhippocampus.Theexpressionlevel oftheiron-exportproteinferroportin1(FPN1)significantlydecreased,whiletheexpressionoftransferrinreceptor1(TfR1) wasincreased.InordertoelucidatethemechanismsofFPN1regulation,westudiedtheexpressionofthekeyregulatorof FPN1,hepcidin.Weobservedthatthehepcidinlevelwassignificantlyelevatedintheischemicsideofthebrain.Knockdown hepcidinrepressedtheincreasingofL-ferritinanddecreasingofFPN1invokedbyischemia-reperfusion.Theresultsindicate thathepcidinisanimportantcontributortoironoverloadincerebralischemia.Furthermore,ourresultsdemonstratedthat thelevelsofhypoxia-induciblefactor-1a(HIF-1a)weresignificantlyhigherinthecerebralcortex,hippocampusandstriatum ontheischemicside;therefore,theHIF-1a-mediatedTfR1expressionmaybeanothercontributortotheironoverloadinthe ischemia-reperfusionbrain. Citation: Ding H, Yan C-Z, Shi H, Zhao Y-S, Chang S-Y, et al.