High Prevalence of Cardio-Metabolic Risk Factors in a Young Urban Sri-Lankan Population 英文参考文献.docVIP

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High Prevalence of Cardio-Metabolic Risk Factors in a Young Urban Sri-Lankan Population 英文参考文献.doc

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High Prevalence of Cardio-Metabolic Risk Factors in a Young Urban Sri-Lankan Population 英文参考文献

HighPrevalenceofCardio-MetabolicRiskFactorsina YoungUrbanSri-LankanPopulation MahenWijesuriya1,MartinGulliford3,JudithCharlton3,LakshaVasantharaja1,GiancarloViberti2 ,Luigi Gnudi2,JanakaKaralliedde2* 1DiabetesAssociationofSriLanka,NationalDiabetesCentre,Colombo,SriLanka,2CardiovascularDivision,King’sCollegeLondon,London,UnitedKingdom,3Division ofHealthandSocialCareResearch,King’sCollegeLondon,London,UnitedKingdom Abstract Background:South-Asian’sarepredisposedtoearlyonsettype2diabetes(T2DM).Theprevalenceofcardio-metabolicrisk- factorsinyoungSri-Lankansisunknown. Methodology/PrincipalFindings:Todeterminebyquestionnaireandanthropometrytheprevalenceoffirstdegreefamily history (FH) of T2DM, physical inactivity, raised waist circumference (WC) and raised body mass index (BMI) in a representative healthy urban population selected by cluster sampling. Those with $2 risk-factors were evaluated for metabolicsyndrome(MS)andrecruitedforaninterventiontrial.Of23,296participantsscreened,22,507(53%Female)were eligible[8,497aged10–14yrs,4,763aged15–19yrsand9,247aged20–40yrs].51%hadnoneofthe4risk-factors,26%1 risk-factorand23%(5,163)$2risk-factorsofwhom4,532wereassessedforMS.RaisedBMIwasnotedin19.7%aged10– 14yrs, 15.3% between 15–19yrs, and between 20–40yrs, 27.4% of males vs. 21.8% of females p,0.001. Prevalence of raisedWCwasgreaterinfemalesforeachagegroup:42.7%vs.32.1%;28.1%vs.16.1%;34.5%vs.25.7%(p,0.05forall)as wasphysicalinactivity:39.9%vs.14.5%;51.7%vs.20.0%;62.7%vs.41.3%whichroseinbothsexeswithage(p,0.05forall). FHofT2DMwaspresentin26.2%.In4532(50%,16yrs)with$2risk-factors,impairedfastingglycaemia/impairedglucose tolerance(pre-diabetes)prevalencewas16%.MSwasmoreprevalentinmales[10–16yrs(13.0%vs.8.8%),16–40yrs(29.5% vs.20.0%)p,0.001forboth]. Conclusions/Significance:Thereisahighprevalenceofmodifiablecardio-metabolicrisk-factorsinyoungurbanSri-Lankans with significant gender differences. A primary prevention intervention trial is ongoing in this cohort. Clinical Trial Registr