Maternal Serum Heme-Oxygenase-1 (HO-1) Concentrations in Early Pregnancy and Subsequent Risk of Gestational Diabetes Mellitus 英文参考文献.docVIP

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Maternal Serum Heme-Oxygenase-1 (HO-1) Concentrations in Early Pregnancy and Subsequent Risk of Gestational Diabetes Mellitus 英文参考文献.doc

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Maternal Serum Heme-Oxygenase-1 (HO-1) Concentrations in Early Pregnancy and Subsequent Risk of Gestational Diabetes Mellitus 英文参考文献

MaternalSerumHeme-Oxygenase-1(HO-1) ConcentrationsinEarlyPregnancyandSubsequentRisk ofGestationalDiabetesMellitus ChunfangQiu1*,KarinHevner1,DanielA.Enquobahrie1,2,MichelleA.Williams1,3 1CenterforPerinatalStudies,SwedishMedicalCenter,Seattle,Washington,UnitedStatesofAmerica,2DepartmentofEpidemiology,UniversityofWashingtonSchoolof PublicHealth,Seattle,Washington,UnitedStatesofAmerica,3DepartmentofEpidemiology,HarvardSchoolofPublicHealth,Boston,Massachusetts,UnitedStatesof America Abstract Background: Heme oxygenase-1 (HO-1) concentrations have been recently reported to be elevated in impaired glucose tolerance and type 2 diabetes mellitus (T2DM). However, no study has examined the association between HO-1 concentrationsandgestationaldiabetesmellitus(GDM). Methods:Inacase-controlstudy,nestedwithinaprospectivecohortofpregnantwomen(186GDMcasesand191women who remained eu-glycemic through pregnancy), we assessed the association of maternal serum HO-1 concentrations, measured in samples collected at 16 weeks gestation, on average, with subsequent risk of GDM. Maternal serum HO-1 concentrationsweredeterminedusingELISA.Wefittedmultivariatelogisticregressionmodelstoderiveestimatesofodds ratios(ORs)and95%confidenceintervals(CIs). Results:MedianserumHO-1concentrationsinearlypregnancywerelowerinwomenwhosubsequentlydevelopedGDM compared with those who did not (1.60 vs. 1.80ng/mL, p-value=0.002). After adjusting for maternal age, race, family historyofT2DMandpre-pregnancybodymassindex,womenwithHO-1$3.05ng/mL(highestdecile)experienceda74% reductionofGDMrisk(95%CI;0.09–0.77)comparedwithwomenwhoseconcentrationswere,1.23ng/mL(lowestquartile). Conclusion:SerumHO-1concentrationswereinverselyassociatedwithsubsequentGDMrisk.Thesefindingsunderscore theroleofoxidativestressinthepathogenesisofGDM.Additionalstudiesarewarrantedtoconfirmtheclinicalutilityof serumHO-1indiagnosisofGDM,particularlyintheearlypregnancy. Citation:QiuC,HevnerK,EnquobahrieDA,WilliamsMA(2012)MaternalSerumHeme-Oxygenase-