Methylenetetrahydrofolate Reductase C677T Polymorphism and Susceptibility to Cervical Cancer and Cervical Intraepithelial Neoplasia A Meta-Analysis 英文参考文献.docVIP

下载本文档

6
0
约3.57万字
约 7页
2017-05-12 发布于上海
举报
版权申诉

Methylenetetrahydrofolate Reductase C677T Polymorphism and Susceptibility to Cervical Cancer and Cervical Intraepithelial Neoplasia A Meta-Analysis 英文参考文献.doc

1、原创力文档（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。。
2、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击这里二次下载。
3、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。
4、该文档为VIP文档，如果想要下载，成为VIP会员后，下载免费。
5、成为VIP后，下载本文档将扣除1次下载权益。下载后，不支持退款、换文档。如有疑问请联系我们。
6、成为VIP后，您将拥有八大权益，权益包括：VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
7、VIP文档为合作方或网友上传，每下载1次，网站将根据用户上传文档的质量评分、类型等，对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档

Methylenetetrahydrofolate Reductase C677T Polymorphism and Susceptibility to Cervical Cancer and Cervical Intraepithelial Neoplasia A Meta-Analysis 英文参考文献

MethylenetetrahydrofolateReductaseC677T PolymorphismandSusceptibilitytoCervicalCancerand CervicalIntraepithelialNeoplasia:AMeta-Analysis YaLiLuo.,PingYe.,QiongHuaZhang,TingTingHu,MinHongLuo,MeiQingLi,QingChen* DepartmentofEpidemiology,SchoolofPublicHealthandTropicalMedicine,SouthernMedicalUniversity,Guangzhou,China Abstract Background:Anumberofstudieshaveexploredtheassociationbetweenmethylenetetrahydrofolatereductase(MTHFR) C677T polymorphism and susceptibility to cervical cancer and cervical intraepithelial neoplasia (CIN). However, results remainedcontroversial.Toaddressthisgap,wedecidedtoconductameta-analysisofallavailablepublishedstudies. Methods: Electronic literature searches of the PubMed, EmBase and Medline databases were performed up to April 30, 2012.Fixed-effectsorrandom-effectsmodelwasusedtocalculatethepooledORsfordifferentgeneticmodels. Results:Atotalof12case-controlstudieswereultimatelyidentified.NostatisticalcorrelationwasfoundbetweenC677T variants and cervical cancer for the overall population. However, subgroup analyses on the White women pointed to a significantprotectiveeffectforindividualsheterozygousorhomozygousfortheT-allele(forCTvs.CC:OR=0.72,95%CI 0.59–0.88;forTTvs.CC:OR=0.69,95%CI=0.49–0.97;forCT+TTvs.CC:OR=0.71,95%CI0.59–0.86).C677Tvariantswere associatedwithneithercombinednorstratifiedCINamongtheoverallpopulation. Conclusions: This meta-analysis suggests that White women with mutant C677T genotypes might have a lower risk of cervicalcancer,yetlackingenoughstatisticalrobustness.Furtherinvestigationsareneededtogetmoreinsightintotherole ofthispolymorphismincervicalcarcinogenesis. Citation:LuoYL,YeP,ZhangQH,HuTT,LuoMH,etal.(2012)MethylenetetrahydrofolateReductaseC677TPolymorphismandSusceptibilitytoCervicalCancer andCervicalIntraepithelialNeoplasia:AMeta-Analysis.PLoSONE7(9):e46272.doi:10.1371/journal.pone.0046272 Editor:Xiao-PingMiao,MOEKeyLaboratoryofEnvironmentandHealth,SchoolofPublicHealth,TongjiMedicalCollege,HuazhongUniversityofSciencea