New Insights into Alzheimers Disease Progression A Combined TMS and Structural MRI Study 英文参考文献.docVIP

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New Insights into Alzheimers Disease Progression A Combined TMS and Structural MRI Study 英文参考文献.doc

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New Insights into Alzheimers Disease Progression A Combined TMS and Structural MRI Study 英文参考文献

NewInsightsintoAlzheimer’sDiseaseProgression:A CombinedTMSandStructuralMRIStudy EiniNiskanen1,2*,MerviKo¨no¨nen2,3,SaraMa¨a¨tta¨3,MerjaHallikainen4,MiiaKivipelto4,5 ,Silvia Casarotto6,MarcelloMassimini6,RitvaVanninen2,7,EsaMervaala3,8,JariKarhu9,10,HilkkaSoininen4,11 1Department of Applied Physics, University of Eastern Finland, Kuopio, Finland, 2Department of Clinical Radiology, Kuopio University Hospital, Kuopio, Finland, 3DepartmentofClinicalNeurophysiology,KuopioUniversityHospital,Kuopio,Finland,4InstituteofClinicalMedicine,Neurology,UniversityofEasternFinland,Kuopio, Finland, 5AgingResearchCenter, Karolinska Institutet,Stockholm,Sweden, 6Department ofClinical Sciences ‘‘L.Sacco’’,Universita` degliStudi diMilano,Milan,Italy, 7InstituteofClinicalMedicine,ClinicalRadiology,UniversityofEasternFinland,Kuopio,Finland,8InstituteofClinicalMedicine,ClinicalNeurophysiology,Universityof Eastern Finland, Kuopio, Finland, 9Nexstim Ltd, Helsinki, Finland, 10Department of Physiology, University of Eastern Finland, Kuopio, Finland, 11Department of Neurology,KuopioUniversityHospital,Kuopio,Finland Abstract Background: Combination of structural and functional data of the human brain can provide detailed information of neurodegenerativediseasesandtheinfluenceofthediseaseonvariouslocalcorticalareas. MethodologyandPrincipalFindings:Toexaminetherelationshipbetweenstructureandfunctionofthebrainthecortical thicknessbasedonstructuralmagneticresonanceimagesandmotorcortexexcitabilityassessedwithtranscranialmagnetic stimulation were correlated in Alzheimer’s disease (AD) and mild cognitive impairment (MCI) patients as well as in age- matchedhealthycontrols.Motorcortexexcitabilitycorrelatednegativelywithcorticalthicknessonthesensorimotorcortex, theprecuneusandthecuneusbutthestrengthofthecorrelationvariedbetweenthestudygroups.Onthesensorimotor cortexthecorrelation wassignificantonlyin MCIsubjects. Ontheprecuneus andcuneusthecorrelation wassignificant bothinADandMCIsubjects.Inhealthy