NSAIDs, Opioids, Cannabinoids and the Control of Pain by the Central Nervous System 英文参考文献.docVIP
- 1、本文档共13页,可阅读全部内容。
- 2、原创力文档(book118)网站文档一经付费(服务费),不意味着购买了该文档的版权,仅供个人/单位学习、研究之用,不得用于商业用途,未经授权,严禁复制、发行、汇编、翻译或者网络传播等,侵权必究。
- 3、本站所有内容均由合作方或网友上传,本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺!文档内容仅供研究参考,付费前请自行鉴别。如您付费,意味着您自己接受本站规则且自行承担风险,本站不退款、不进行额外附加服务;查看《如何避免下载的几个坑》。如果您已付费下载过本站文档,您可以点击 这里二次下载。
- 4、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等,请点击“版权申诉”(推荐),也可以打举报电话:400-050-0827(电话支持时间:9:00-18:30)。
- 5、该文档为VIP文档,如果想要下载,成为VIP会员后,下载免费。
- 6、成为VIP后,下载本文档将扣除1次下载权益。下载后,不支持退款、换文档。如有疑问请联系我们。
- 7、成为VIP后,您将拥有八大权益,权益包括:VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
- 8、VIP文档为合作方或网友上传,每下载1次, 网站将根据用户上传文档的质量评分、类型等,对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档
查看更多
NSAIDs, Opioids, Cannabinoids and the Control of Pain by the Central Nervous System 英文参考文献
Pharmaceuticals 2010, 3, 1335-1347; doi:10.3390/ph3051335
OPEN ACCESS
pharmaceuticals
ISSN 1424-8247
/journal/pharmaceuticals
Review
NSAIDs, Opioids, Cannabinoids and the Control of Pain by the
Central Nervous System
Horacio Vanegas *, Enrique Vazquez and Victor Tortorici
Instituto Venezolano de Investigaciones Cientificas (IVIC), Apartado 20632, Caracas 1020A,
Venezuela; E-Mails: enriquevr@ (E.V.); victort@ivic.gob.ve (V.T.)
* Author to whom correspondence should be addressed; E-Mail: horaciovan@;
Tel.: +58-212-504-1456; Fax: +58-212-504-1093
Received: 23 March 2010; in revised form: 14 April 2010 / Accepted: 21 April 2010/
Published: 29 April 2010
Abstract: Nonsteroidal anti-inflammatory drugs (NSAIDs) act upon peripheral tissues and
upon the central nervous system to produce analgesia. A major central target of NSAIDs is
the descending pain control system. The rostral structures of the descending pain control
system send impulses towards the spinal cord and regulate the transmission of pain
messages. Key structures of the descending pain control system are the periaqueductal gray
matter (PAG) and the rostral ventromedial region of the medulla (RVM), both of which are
critical targets for endogenous opioids and opiate pharmaceuticals. NSAIDs also act upon
PAG and RVM to produce analgesia and, if repeatedly administered, induce tolerance to
themselves and cross-tolerance to opioids. Experimental evidence shows that this is due to
an interaction of NSAIDs with endogenous opioids along the descending pain control
system. Analgesia by NSAIDs along the descending pain control system also requires an
activation of the CB1 endocannabinoid receptor. Several experimental approaches suggest
that opioids, NSAIDs and cannabinoids in PAG and RVM cooperate to decrease
GABAergic inhibition and thus enhance the descending flow of impulses that inhibit pain.
Keywords: NSAID; opioid; cannabinoid; descending pain
您可能关注的文档
- Novel Vaccines to Human Rabies 英文参考文献.doc
- Novel Ultra-Sensitive Detectors in the 10–50 μm Wavelength Range 英文参考文献.doc
- Novel venom gene discovery in the platypus 英文参考文献.doc
- Novel Wireless Sensor System for Dynamic Characterization of Borehole Heat Exchangers 英文参考文献.doc
- Novo, S. et al. Aliskiren Just a New Drug for Few Selected Patients or an Innovative Molecule Predestinated to Replace Arbs and Ace-Inhibitors Pharmaceuticals 2009, 2, 118-124 英文参考文献.doc
- Novel, Meso-Substituted Cationic Porphyrin Molecule for Photo-Mediated Larval Control of the Dengue Vector Aedes aegypti 英文参考文献.doc
- Novel Wireless Sensor System for Monitoring Oxygen, Temperature and Respiration Rate of Horticultural Crops Post Harvest 英文参考文献.doc
- NPR1 Protein Regulates Pathogenic and Symbiotic Interactions between Rhizobium and Legumes and Non-Legumes 英文参考文献.doc
- Now You Don't See It, Now You Do Filling In Creates the Illusion of Motion 英文参考文献.doc
- NR-2L A Two-Level Predictor for Identifying Nuclear Receptor Subfamilies Based on Sequence-Derived Features 英文参考文献.doc
- 2024延安延川县特岗教师招聘笔试备考试题及答案解析.docx
- 2024湖南长沙市长郡外国语实验中学教师招聘笔试模拟试题及答案解析.docx
- 2024湖南长沙市文学艺术界联合会招聘普通雇员笔试模拟试题及答案解析.docx
- 2024年浙江事业单位招聘-共青团浙江省委所属省青少年发展基金会、省青年创业就业基金会招聘2人笔试模拟试题及答案解析.docx
- 2024年浙江事业单位招聘-湖州德清县生态环境保护行政执法队编外招聘1人笔试模拟试题及答案解析.docx
- 2024年宁德蕉城区中小学新任教师补充招聘笔试备考试题及答案解析.docx
- 2024年浙江事业单位招聘-杭州浙江金融职业学院招聘6人笔试备考试题及答案解析.docx
- 2024福建云上南岭文旅有限公司招聘8人笔试备考试题及答案解析.docx
- 2024广东东莞理工学院招聘教师招聘11人笔试模拟试题及答案解析.docx
- 2024甘肃张掖市甘州区招聘中小学幼儿园教师76人笔试备考试题及答案解析.docx
文档评论(0)