Nuclear processes controlled by molecular machines 英文参考文献.docVIP

/2002/3/6/reports/4016.1 Meeting report Nuclear processes controlled by molecular machines Archa H Fox and Angus I Lamond Address: Wellcome Trust Biocentre, University of Dundee, Dundee DD1 5EH, UK. Correspondence: Angus I Lamond. E-mail: a.i.lamond@dundee.ac.uk Published: 23 May 2002 GenomeBiology 2002, 3(6):reports4016.1–4016.3 The electronic version of this article is the complete one and can be found online at /2002/3/6/reports/4016 ? BioMed Central Ltd (Print ISSN 1465-6906; Online ISSN 1465-6914) part of the nucleus from active genes. Van Driel hypothesized A report on the ‘Nuclear Structure and Function’ that the cell uses the Polycomb-group proteins for silencing when it cannot use proximity to heterochromatin as a silencing method, that is, Polycomb-group proteins are used to silence genes that are interspersed with transcriptionally active genes. symposium at the joint spring meeting of the British Society for Cell Biology, British Society for Developmental Biology and Genetics Society, York, UK, 20-23 March 2002. Van Driel also used time-lapse imaging of cells stably expressing GFP-H2B as they completed mitosis to analyze chromatin decondensation (loosening of tightly packed mitotic chromatin). He reported an approximately five-fold increase in nuclear volume and a concomitant approximately five-fold decondensation of the chromatin at the end of mitosis, indicating that chromatin actually shows a surprisingly limited degree of overall decondensation. To study local chromatin decondensation, Van Driel used Arabidopsis as a model system. Subsets of specific chromosome regions were The dynamic nucleus Recent years have seen a dramatic increase in our under- standing of the way the nucleus is organized; for example, we now know that many nuclear proteins, although restricted to particular compartments, are also very dynamic and can move rapidly between s