Ocular Axial Length and Its Associations in Chinese The Beijing Eye Study 英文参考文献.docVIP

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Ocular Axial Length and Its Associations in Chinese The Beijing Eye Study 英文参考文献.doc

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Ocular Axial Length and Its Associations in Chinese The Beijing Eye Study 英文参考文献

OcularAxialLengthandItsAssociationsinChinese:The BeijingEyeStudy GuoYin1,YaXingWang1,ZhiYunZheng2,HuaYang1,LiangXu1*,JostB.Jonas1,3,theBeijingEyeStudy Group 1BeijingInstituteofOphthalmology,BeijingTongrenHospital,CapitalMedicalUniversity,Beijing,China,2YayuncunClinics,PLAGeneralArmamentDepartment,Beijing, China,3DepartmentofOphthalmology,MedicalFacultyMannheimoftheRuprecht-Karls-University,Heidelberg,Germany Abstract Purpose:ToinvestigatethenormativedataofocularaxiallengthanditsassociationsinChinese. Method:Thepopulation-basedBeijingEyeStudy2011isacross-sectionalstudyperformedinGreaterBeijing.Thestudy included 3468 individuals (1963 (56.6%) women) with a mean age of 64.669.8 years (range: 50–93 years). A detailed ophthalmicandmedicalexaminationwasperformed.Axiallengthwasmeasuredbyopticallow-coherencereflectometry. Results: Axial length measurements were available for 3159 (91.1%) study participants. Mean axial length was 23.2561.14mm (range: 18.96–30.88mm). In multivariate analysis, axial length was significantly associated with the systemicparametersofhigherage(P,0.001),higherbodyheight(P=0.003),higherlevelofeducation(P,0.001)andurban region of habitation (P,0.001), and with the ocular parameters of thicker central cornea (P=0.001), higher corneal curvature radius (P,0.001), deeper anterior chamber (P,0.001), thicker lens (P,0.001), more myopic refractive error (P,0.001), larger pupil diameter (P=0.018), and higher best corrected visual acuity (P,0.001). It was additionally and negativelyassociatedwiththelensvault(P,0.001).Inhighlymyopic eyes,axial lengthwassignificantlyassociated with lower level of education (P=0.008), more myopic refractive error (P,0.001), and lower best corrected visual acuity (P=0.034). Conclusions:MeanocularaxiallengthintheolderadultpopulationofGreaterBeijing(23.2561.14mm)wassimilartothe value measured in other urban populations and was higher than in a rural Central Indian population. The association between axiallength andoldera