On the Mechanics of Cardiac Function of Drosophila Embryo 英文参考文献.docVIP

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On the Mechanics of Cardiac Function of Drosophila Embryo 英文参考文献.doc

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On the Mechanics of Cardiac Function of Drosophila Embryo 英文参考文献

OntheMechanicsofCardiacFunctionofDrosophila Embryo MingmingWu1.,ThomasN.Sato2. * 1The Sibley School of Mechanical and Aerospace Engineering, and the Department of Chemical and Biomolecular Engineering, Cornell University, Ithaca, New York, UnitedStatesofAmerica,2DepartmentofCellandDevelopmentalBiology,WeillMedicalCollegeofCornellUniversity,NewYork,NewYork,UnitedStatesofAmerica Abstract Theheartisavitalorganthatprovidesessentialcirculationthroughoutthebody.Malfunctionofcardiacpumping,thus, leadstoseriousandmostofthetimes,tofataldiseases.Mechanicsofcardiacpumpingisacomplexprocess,andmany experimentalandtheoreticalapproacheshavebeenundertakentounderstandthisprocess.Wehavetakenadvantageof the simplicity of the embryonic heart of an invertebrate, Drosophila melanogaster, to understand the fundamental mechanics of the beating heart. We applied a live imaging technique to the beating embryonic heart combined with analyticalimagingtoolstostudythedynamicmechanicsofthepumping.Furthermore,wehaveidentifiedonemutantline that exhibits aberrant pumping mechanics. The Drosophila embryonic heart consists of only 104 cardiac cells forming a simplestraighttubethatcanbeeasilyaccessedforreal-timeimaging.Therefore,combinedwiththewealthofavailable genetictools,theembryonicDrosophilaheartmayserveasapowerfulmodelsystemforstudiesofhumanheartdiseases, such as arrhythmia and congenital heart diseases. We, furthermore, believe our mechanistic data provides important information that is useful for our further understanding of the design of biological structure and function and for engineeringthepumpsformedicaluses. Citation:WuM,SatoTN(2008)OntheMechanicsofCardiacFunctionofDrosophilaEmbryo.PLoSONE3(12):e4045.doi:10.1371/journal.pone.0004045 Editor:ChristopheEgles,TuftsUniversity,UnitedStatesofAmerica ReceivedSeptember2,2008;AcceptedNovember23,2008;PublishedDecember24,2008 Copyright:?2008Wuetal.Thisisanopen-accessarticledistributedunderthetermsoftheCreativeCommonsAttributionLicense,whichpermitsu