Open Release of Male Mosquitoes Infected with a Wolbachia Biopesticide Field Performance and Infection Containment 英文参考文献.docVIP

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Open Release of Male Mosquitoes Infected with a Wolbachia Biopesticide Field Performance and Infection Containment 英文参考文献.doc

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Open Release of Male Mosquitoes Infected with a Wolbachia Biopesticide Field Performance and Infection Containment 英文参考文献

OpenReleaseofMaleMosquitoesInfectedwitha WolbachiaBiopesticide:FieldPerformanceandInfection Containment LindaO’Connor1,CatherinePlichart2,AyoCheongSang2,CoreyL.Brelsfoard1,Herve′ C.Bossin2, StephenL.Dobson1* 1DepartmentofEntomology,UniversityofKentucky,Lexington,Kentucky,UnitedStatesofAmerica,2InstitutLouisMalarde′,Papeete,Tahiti,FrenchPolynesia Abstract Background: Lymphatic filariasis (LF) is a globally significant disease, with 1.3 billion persons in 83 countries at risk. A coordinatedeffortofadministeringannualmacrofilaricidalprophylacticstotheentireat-riskpopulationhassucceededin impactingandeliminatingLFtransmissioninmultipleregions.However,someareasintheSouthPacificarepredictedto persistastransmissionsites,dueinparttothebiologyofthemosquitovector,whichhasledtoacallforadditionaltoolsto augmentdrugtreatments.Autocidalstrategiesagainstmosquitoesareresurgingintheeffortagainstinvasivemosquitoes and vector borne disease, with examples that include field trials of genetically modified mosquitoes and Wolbachia population replacement. However, critical questions must be addressed in anticipation of full field trials, including assessmentsoffieldcompetitivenessoftransfectedmalesandtheriskofunintendedpopulationreplacement. Methodology/PrincipalFindings:WereporttheoutcomeoffieldexperimentstestingastrategythatemploysWolbachiaas abiopesticide.ThestrategyisbaseduponWolbachia-inducedconditionalsterility,knownascytoplasmicincompatibility, and the repeated release of incompatible males to suppress a population. A criticism of the Wolbachia biopesticide approach is that unintended female release or horizontal Wolbachia transmission can result in population replacement instead of suppression. We present the outcome of laboratory and field experiments assessing the competitiveness of transfectedmalesandtheirabilitytotransmitWolbachiaviahorizontaltransmission. Conclusions/Significance: The results demonstrate that Wolbachia-transfected Aedes polynesiensis males are compet