Ovarian Cancer and Body Size Individual Participant Meta-Analysis Including 25,157 Women with Ovarian Cancer from 47 Epidemiological Studies 英文参考文献.docVIP

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Ovarian Cancer and Body Size Individual Participant Meta-Analysis Including 25,157 Women with Ovarian Cancer from 47 Epidemiological Studies 英文参考文献.doc

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Ovarian Cancer and Body Size Individual Participant Meta-Analysis Including 25,157 Women with Ovarian Cancer from 47 Epidemiological Studies 英文参考文献

OvarianCancerandBodySize:IndividualParticipant Meta-AnalysisIncluding25,157WomenwithOvarian Cancerfrom47EpidemiologicalStudies CollaborativeGrouponEpidemiologicalStudiesofOvarianCancer* CancerEpidemiologyUnit,UniversityofOxford,Oxford,UnitedKingdom Abstract Background:Onlyabouthalfthestudiesthathavecollectedinformationontherelevanceofwomen’sheightandbody massindextotheirriskofdevelopingovariancancerhavepublishedtheirresults,andfindingsareinconsistent.Here,we bringtogethertheworldwideevidence,publishedandunpublished,anddescribetheserelationships. MethodsandFindings:Individualdataon25,157womenwithovariancancerand81,311womenwithoutovariancancer from47epidemiologicalstudieswerecollected,checked,andanalysedcentrally.Adjustedrelativerisksofovariancancer werecalculated,byheightandbybodymassindex. Ovariancancerriskincreasedsignificantlywithheightandwithbody massindex,exceptinstudiesusinghospitalcontrols.Forotherstudydesigns,therelativeriskofovariancancerper5cm increaseinheightwas1.07(95%confidenceinterval[CI],1.05–1.09;p,0.001);thisrelationshipdidnotvarysignificantlyby women’sage,yearofbirth,education,ageatmenarche,parity,menopausalstatus,smoking,alcoholconsumption,having had a hysterectomy, having first degree relatives with ovarian or breast cancer, use of oral contraceptives, or use of menopausalhormonetherapy.Forbodymassindex,therewassignificantheterogeneity(p,0.001)inthefindingsbetween ever-usersandnever-usersofmenopausalhormonetherapy,butnotbythe11otherfactorslistedabove.Therelativerisk forovariancancerper5kg/m2increaseinbodymassindexwas1.10(95%CI,1.07–1.13;p,0.001)innever-usersand0.95 (95%CI,0.92–0.99;p=0.02)inever-usersofhormonetherapy. Conclusions:Ovariancancerisassociatedwithheightand,amongnever-usersofhormonetherapy,withbodymassindex. In high-income countries, both height and body mass index have been increasing in birth cohorts now developing the disease.Ifallotherrelevantfactorshadremainedconstant,thentheseincreasesinheightandweightwouldbeassociated witha