Oxytocin in the Circadian Timing of Birth 英文参考文献.docVIP

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Oxytocin in the Circadian Timing of Birth 英文参考文献.doc

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Oxytocin in the Circadian Timing of Birth 英文参考文献

OxytocinintheCircadianTimingofBirth JeffreyRoizen1,2,3,ChristinaE.Luedke4,ErikD.Herzog5,LouisJ.Muglia1,2,3* 1Department of Pediatrics, Washington University School of Medicine, St. Louis, Missouri, United States of America, 2Department of Molecular BiologyandPharmacology,WashingtonUniversitySchoolofMedicine,St.Louis,Missouri,UnitedStatesofAmerica,3DepartmentofObstetricsand Gynecology,WashingtonUniversitySchoolofMedicine,St.Louis,Missouri,UnitedStatesofAmerica,4DivisionofEndocrinology,Children’sHospital, Boston,Massachusetts,UnitedStatesofAmerica,5DepartmentofBiology,WashingtonUniversity,StLouis,Missouri,UnitedStatesofAmerica Background. The molecular components determining the timing for birth remain an incompletely characterized aspect of reproduction,withimportantconceptualandtherapeuticramificationsformanagementofpreterm,post-termandarrested labor. Methodology/Principal Findings. To test the hypothesis that oxytocin mediates circadian regulation of birth, we evaluatedparturitiontimingfollowingshiftsinlightcyclesinoxytocin(OT)-deficientmice.Wefindthat,incontrasttowild typemicethatdonotshiftthetimingofbirthfollowinga6-hadvanceordelayinthelightcycle,OT-deficientmicedeliveredat random times of day. Moreover, shifts in the light-dark cycle of gravid wild type mice have little impact on the pattern of circadian oxytocin release. Conclusions/Significance. Our results demonstrate oxytocin plays a critical role in minimizing labordisruptionduetocircadianclockresetting. Citation: Roizen J, Luedke CE, Herzog ED, Muglia LJ (2007) Oxytocin in the Circadian Timing of Birth. PLoS ONE 2(9): e922. doi:10.1371/ journal.pone.0000922 INTRODUCTION laborinOTKOmiceshiftedforwardorbackwardwasdistributed randomly with respect to time of day (shifted forward vector magnitude 0.56, n=8, P=0.08, n=8; shifted backward vector magnitude0.20,n=10,P=0.68).Furthermore,inthebackward shiftedOTKOmice,twomicediedduetofailedlabor.Thus,in the absence of a shift, labor timing in OT KO mice is indist