Parental Death during Childhood and Adult Cardiovascular Risk in a Developing Country The Guangzhou Biobank Cohort Study 英文参考文献.docVIP

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Parental Death during Childhood and Adult Cardiovascular Risk in a Developing Country The Guangzhou Biobank Cohort Study 英文参考文献.doc

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Parental Death during Childhood and Adult Cardiovascular Risk in a Developing Country The Guangzhou Biobank Cohort Study 英文参考文献

ParentalDeathduringChildhoodandAdult CardiovascularRiskinaDevelopingCountry:The GuangzhouBiobankCohortStudy C.MarySchooling1,4*,ChaoQiangJiang2,TaiHingLam1,WeiSenZhang2,KarKeungCheng3,GabrielM. Leung1 1DepartmentofCommunityMedicine,SchoolofPublicHealth,TheUniversityofHongKong,HongKongSAR,China,2GuangzhouOccupationalDiseasesPreventionand TreatmentCentre,GuangzhouNumber12Hospital,Guangzhou,China,3DepartmentofPublicHealthandEpidemiology,UniversityofBirmingham,Birmingham,United Kingdom,4SchoolofPublicHealth,TheCityUniversityofNewYork(CUNY),NewYork,NewYork,UnitedStatesofAmerica Abstract Background:Inobservationalstudiesfromwesterncountrieschildhoodemotionaladversityisusuallyassociatedwithadult cardiovascular disease. These findings are open to contextual biases making evidence from other settings valuable. We examinedtheassociationofapotentialmarkerofchildhoodemotionaladversitywithcardiovasculardiseaseriskfactorsina developingcountry. Methods: We used multivariable regression in cross-sectional analysis of older ($50 years) men (n=7,885) and women (n=20,886) from the Guangzhou Biobank Cohort Study (2003–8) to examine the adjusted association of early life (,18 years) parental death (none, one or two deaths) with blood pressure, fasting glucose, LDL-cholesterol, HDL-cholesterol, triglycerides,bodymassindex(BMI),waist-hipratio(WHR)andwhitebloodcellcount(WBC).Weusedseatedheightand delayed10-wordrecalltoassesscontentvalidityofparentaldeathasameasureofchildhoodemotionaladversity.Wealso examinedwhetherassociationsvariedbysex. Results:Earlylifeparentaldeathwasassociatedwithshorterage-andsex-adjustedseatedheight.Itwasalsoassociated withlower10-wordrecallscoreadjustedforage,sex,socio-economicposition,leglengthandlifestyle.Similarly,adjusted earlylifeparentaldeathwasnotassociatedwithbloodpressure,fastingglucose,LDL-cholesterolorHDL-cholesterolbut was associated with lower BMI (20.40, 95% confidence interval (CI) 20.62 to 20.19 for 2 compared with no early life parentaldeaths)and