Pathogenic Roles of CD14, Galectin-3, and OX40 during Experimental Cerebral Malaria in Mice 英文参考文献.docVIP

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Pathogenic Roles of CD14, Galectin-3, and OX40 during Experimental Cerebral Malaria in Mice 英文参考文献.doc

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Pathogenic Roles of CD14, Galectin-3, and OX40 during Experimental Cerebral Malaria in Mice 英文参考文献

PathogenicRolesofCD14,Galectin-3,andOX40during ExperimentalCerebralMalariainMice MirandaS.Oakley1,VictoriaMajam2,BabitaMahajan2,NoelGerald2,VivekAnantharaman3,JerroldM. Ward4,LawrenceJ.Faucette4,ThomasF.McCutchan5,HongZheng2,MasakiTerabe6,JayA.Berzofsky6, L.Aravind3,SanjaiKumar2* 1DivisionofBacterial,ParasiticandAllergenicProducts,CenterforBiologicsandEvaluationResearch,FoodandDrugAdministration,Bethesda,Maryland,UnitedStatesof America,2DivisionofEmergingandTransfusionTransmittedDiseases,CenterforBiologicsandEvaluationResearch,FoodandDrugAdministration,Rockville,Maryland, UnitedStatesofAmerica,3NationalCenterforBiotechnologyInformation,NationalLibraryofMedicine,NationalInstitutesofHealth,Bethesda,Maryland,UnitedStatesof America,4InfectiousDiseasePathogenesisSection,NationalInstituteofAllergyandInfectiousDiseases,NationalInstitutesofHealth,Rockville,Maryland,UnitedStatesof America,5LaboratoryofMalariaandVectorResearch,NationalInstituteofAllergyandInfectiousDiseases,NationalInstitutesofHealth,Rockville,Maryland,UnitedStates ofAmerica,6VaccineBranch,CenterforCancerResearch,NationalCancerInstitute,NationalInstitutesofHealth,Bethesda,Maryland,UnitedStatesofAmerica Abstract An in-depth knowledge of the host molecules and biological pathways that contribute towards the pathogenesis of cerebralmalariawouldhelpguidethedevelopmentofnovelprognosticsandtherapeutics.Genome-widetranscriptional profilingofthebraintissueduringexperimentalcerebralmalaria(ECM)causedbyPlasmodiumbergheiANKAparasitesin mice,awellestablishedsurrogateofhumancerebralmalaria,hasbeenusefulinpredictingthefunctionalclassesofgenes involvedandpathwaysalteredduringthecourseofdisease.Tofurtherunderstandthecontributionofindividualgenesto thepathogenesisofECM,weexaminedthebiologicalrelevanceofthreemolecules–CD14,galectin-3,andOX40thatwere previouslyshowntobeoverexpressedduringECM.WefindthatCD14playsapredominantroleintheinductionofECMand regulation of parasite density; deletion of the CD14 gene not only prevented t