Pathological femoral fractures due to osteomalacia associated with adefovir dipivoxil treatment for hepatitis B a case report 英文参考文献.docVIP

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Pathological femoral fractures due to osteomalacia associated with adefovir dipivoxil treatment for hepatitis B a case report 英文参考文献.doc

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Pathological femoral fractures due to osteomalacia associated with adefovir dipivoxil treatment for hepatitis B a case report 英文参考文献

Tanakaetal.DiagnosticPathology2012,7:108 /content/7/1/108 CASE REPORT OpenAccess Pathologicalfemoralfracturesdueto osteomalaciaassociatedwithadefovirdipivoxil treatmentforhepatitisB:acasereport MotoyukiTanaka1,TakaoSetoguchi2*,YasuhiroIshidou3,YoshiyaArishima1,MasatakaHirotsu1,YoshinobuSaitoh1, ShunsukeNakamura1,HironoriKakoi1,SatoshiNagano1,MasahiroYokouchi1,JunichiKamizono1 andSetsuroKomiya1 Abstract Wepresentacaseofa62-year-oldmanwhounderwenttotalhiparthroplastyfortreatmentofpathologicfemoral neckfractureassociatedwithadefovirdipivoxil-inducedosteomalacia.Hehada13-monthhistoryofbonepain involvinghisshoulders,hips,andknee.Hereceivedadefovirdipivoxilfortreatmentoflamivudine-resistanthepatitis Bvirusinfectionfor5yearsbeforetheoccurrenceoffemoralneckfracture.Orthopedicsurgeonsshouldbeaware ofosteomalaciaandpathologicalhipfracturecausedbydrug-inducedrenaldysfunction,whichresultsinFanconi’s syndrome. Virtualslides:Thevirtualslide(s)forthisarticlecanbefoundhere:http://www.diagnosticpathology.diagnomx.eu/ vs/1600344696739249 Keywords:Osteomalacia,Pathologicalfemoralneckfracture,Adefovirdipivoxil,HepatitisB,Fanconi’ ssyndrome Background a clinic and was administered salazosulfapyridine and Hypophosphatemic osteomalacia caused by proximal methylprednisolone therapy for rheumatoid arthritis. renal tubule dysfunction induces Fanconi’s syndrome, However,thepaingraduallyincreased,andhestartedex- whichleadstoimpairedreabsorptionofaminoacids,glu- periencingpaininhishipjointsaswell.Therefore,hewas cose,urate,andphosphate[1].Thechroniclossofphos- admittedourhospitalforfurtherexaminationinFebruary phateandimpairedsynthesisof1,25-dihydroxyvitaminD3 2011.Hehada7-yearhistoryofchronichepatitiscaused may lead to failure of bone mineralization. Recently, byhepatitisBvirusinfection,andhadreceivedlamivudine osteomalacia was reported in cases in which hepatitis B therapyfor2years.Becausethevirusdevelopedresistance virusandhumanimmunodeficiencyvirus(HIV)infections