Patients with systemic lupus erythematosus have abnormally elevated Epstein–Barr virus load in blood 英文参考文献.docVIP

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Patients with systemic lupus erythematosus have abnormally elevated Epstein–Barr virus load in blood 英文参考文献.doc

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Patients with systemic lupus erythematosus have abnormally elevated Epstein–Barr virus load in blood 英文参考文献

Available online /content/6/4/R295 Research article Open Access Vol 6 No 4 Patients with systemic lupus erythematosus have abnormally elevated Epstein–Barr virus load in blood Uk Yeol Moon1*, Su Jin Park1*, Sang Taek Oh1, Wan-Uk Kim2, Sung-Hwan Park2, Sang- Heon Lee2, Chul-Soo Cho2, Ho-Youn Kim2, Won-Keun Lee3 and Suk Kyeong Lee1 1Research Institute of Immunobiology, Catholic Research Institutes of Medical Science, Catholic University of Korea, Seoul, Korea 2Department of Medicine, The Center for Rheumatic Diseases, Kangnam St. Marys Hospital, Seoul, Korea 3Department of Biological Sciences, Myongji University, Yongin, Kyunggi-do, Korea *Contributed equally Corresponding author: Suk Kyeong Lee, sukklee@cmc.cuk.ac.kr Received: 4 Nov 2003 Revisions requested: 5 Dec 2003 Revisions received: 22 Mar 2004 Accepted: 1 Apr 2004 Published: 7 May 2004 Arthritis Res Ther 2004, 6:R295-R302 (DOI 10.1186/ar1181) /content/6/4/R295 ? 2004 Moon et al.; licensee BioMed Central Ltd. This is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the articles original URL. Abstract Various genetic and environmental factors appear to be involved in systemic lupus erythematosus (SLE). Epstein–Barr virus (EBV) is among the environmental factors that are suspected of predisposing to SLE, based on the characteristics of EBV itself and on sequence homologies between autoantigens and EBV antigens. In addition, higher titers of anti-EBV antibodies and increased EBV seroconversion rates have been observed in SLE patients as compared with healthy control individuals. Serologic responses do not directly reflect EBV status within the body. Clarification of the precise status of EBV infection in SLE patients would help to improve our understanding of the role played by EBV in this disease. In the present study we determined EBV types in SLE