Peak Systolic Velocity of Superior Thyroid Artery for the Differential Diagnosis of Thyrotoxicosis 英文参考文献.docVIP

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Peak Systolic Velocity of Superior Thyroid Artery for the Differential Diagnosis of Thyrotoxicosis 英文参考文献.doc

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Peak Systolic Velocity of Superior Thyroid Artery for the Differential Diagnosis of Thyrotoxicosis 英文参考文献

PeakSystolicVelocityofSuperiorThyroidArteryforthe DifferentialDiagnosisofThyrotoxicosis XiaolongZhao1.,LiliChen1.,LingLi2,YaoWang2,YongWang3,LinuoZhou1,FangfangZeng1, YimingLi1*,RenmingHu1,HongLiu1* 1DepartmentofEndocrinology,HuashanHospital,ShanghaiMedicalCollege,FudanUniversity,Shanghai,China,2DepartmentofEndocrinology,ZhongdaHospitalof SoutheastUniversity,Nanjing,China,3DepartmentofUltrasound,HuashanHospital,ShanghaiMedicalCollege,FudanUniversity,Shanghai,China Abstract Aim:Thedifferentiationofdestruction-inducedthyrotoxicosisandGraves’disease(GD)isofgreatimportanceforselection of proper therapy. Radioactive iodine uptake (RAIU) is the gold standard for differentiating these two conditions but its application has remained somewhat limited. Thyroid color Doppler flow sonography (CDFS) is a potential alternative of RAIUbutmoresupportingevidenceiswarranted.Inthepresentstudy,astandardoperativeprocedurewasdevelopedto measure the mean peak systolic velocity of superior thyroid artery (STA-PSV) and evaluate its role in the differential diagnosisofthyrotoxicosis. Methods: A total of 135 patients with untreated thyrotoxicosis were enrolled into one retrospective study (GD, n=103; thyroiditis, n=32) and another prospective study recruited 169 patients (GD, n=118; thyroiditis, n=51). Thirty normal controlswerealsoenrolled.Thyroidfunction,anti-TSH-receptorantibody(TRAb),RAIU,CFDSofthyroidandSTA-PSVwere performed for each patient. Receiver operator curve (ROC) was used to evaluate the diagnostic value of STA-PSV in a retrospectivestudysoastoseektheoptimalcutoffpoint.Thenthecutoffpointvaluewasusedtovalidateitsdiagnostic valueinaprospectivestudyandinanotherthyrotoxicosispopulation. Results:STA-PSVofGDwassignificantlyhigherthanthatofthyroiditisinbothretrospectiveandprospectivestudies.The areaundertheROCcurveofmeanSTA-PSVwas0.8799and0.9447intheretrospectiveandprospectivestudiesrespectively. IfameanSTA-PSVcutoffpointof50.5cm/swassetfromtheretrospectiveanalysisfortheprospectivest