Pentraxin-3 as a Marker of Advanced Atherosclerosis Results from the Bruneck, ARMY and ARFY Studies 英文参考文献.docVIP

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Pentraxin-3 as a Marker of Advanced Atherosclerosis Results from the Bruneck, ARMY and ARFY Studies 英文参考文献.doc

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Pentraxin-3 as a Marker of Advanced Atherosclerosis Results from the Bruneck, ARMY and ARFY Studies 英文参考文献

Pentraxin-3asaMarkerofAdvancedAtherosclerosis ResultsfromtheBruneck,ARMYandARFYStudies MichaelKnoflach1*,StefanKiechl1,AlbertoMantovani2,3,IvanCuccovillo4,BarbaraBottazzi2 ,Qingbo Xu5,QingzhongXiao5,ArnoGasperi6,AgnesMayr7,MarleneKehrer8,JohannWilleit1,GeorgWick9 1Department of Neurology, Medical University, Innsbruck, Austria, 2Istituto Clinico Humanitas IRCCS, Rozzano, Milan, Italy, 3Department of Translational Medicine, UniversityofMilan,Milan,Italy,4FondazioneHumanitasperlaRicerca,Rozzano,Milan,Italy,5CardiovascularDivision,BHFCentre,King’sCollegeLondon,London,United Kingdom,6DepartmentofNeurology,BruneckHospital,Bruneck,Italy,7DepartmentofLaboratoryMedicine,BruneckHospital,Bruneck,Italy,8DepartmentofInternal Medicine,BruneckHospital,Bruneck,Italy,9LaboratoryofAutoimmunity,Biocenter,Innsbruck,Austria Abstract Objective:PentraxinslikeC-reactiveproteinarekeycomponentsoftheinnateimmunesystem.Recently,pentraxin-3(PTX3) hasbeenproposedtobeaspecificmarkerofvascularinflammation,yetitsassociationwithatherosclerosisisstillunclear. MethodsandResults:PTX3serumlevelsweremeasuredinthreeindependentstudiesof132youngmen(ARMYStudy), 205youngwomen(ARFYStudy)and562individuals55to94yearsold(BruneckStudy).IncontrasttoC-reactiveprotein, PTX3 showed little relationships with classic vascular risk factors and pro-inflammatory conditions. In the population basedBruneckStudy,PTX3levelwasindependentlyassociatedwithprevalentcardiovasculardiseases(multivariableodds ratio [95%CI] 3.09 [1.65–5.79]; P,0.001). Moreover, PTX3 level correlated with the severity of carotid and femoral atherosclerosis and was highest in individuals with multiple vascular territories affected. In contrast, there was no association with elevated intima-media thickness, a precursor lesion of atherosclerosis, in any of the three populations investigated. Conclusions:LevelofPTX3isindependentlyassociatedwithatherosclerosisandmanifestcardiovasculardiseasebutnot earlyvesselpathology.UnlikeC-reactiveprotein,PTX3isnotacomp