Perioperative indocyanine green clearance is predictive for prolonged intensive care unit stay after coronary artery bypass grafting - an observational study 英文参考文献.docVIP

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Perioperative indocyanine green clearance is predictive for prolonged intensive care unit stay after coronary artery bypass grafting - an observational study 英文参考文献.doc

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Perioperative indocyanine green clearance is predictive for prolonged intensive care unit stay after coronary artery bypass grafting - an observational study 英文参考文献

Available online /content/13/5/R149 Research Open Access Vol 13 No 5 Perioperative indocyanine green clearance is predictive for prolonged intensive care unit stay after coronary artery bypass grafting - an observational study Michael Sander1, Claudia D Spies1, Katharina Berger1, Torsten Schr?der1, Herko Grubitzsch2, Klaus D Wernecke3 and Christian von Heymann1 1Department of Anaesthesiology and Intensive Care Medicine, Charité Universit?tsmedizin - Berlin, Campus Virchow Klinikum and Campus Charité Mitte, Charitéplatz 1, 10117 Berlin, Germany 2Department of Cardiovascular Surgery, Charité Universit?tsmedizin - Berlin, Campus Charité Mitte, Charitéplatz 1, 10117 Berlin, Germany 3SOSTANA GmbH, Wildensteiner Str. 27, 10318 Berlin, Germany Corresponding author: Michael Sander, michael.sander@charite.de Received: 28 Apr 2009 Revisions requested: 18 Jun 2009 Revisions received: 12 Aug 2009 Accepted: 14 Sep 2009 Published: 14 Sep 2009 Critical Care 2009, 13:R149 (doi:10.1186/cc8045) This article is online at: /content/13/5/R149 ? 2009 Sander et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Introduction During cardiac surgery with cardiopulmonary bypass (CPB) haemodilution occurs. Hepatic dysfunction after CPB is a rare, but serious, complication. Clinical data have validated the plasma-disappearance rate of indocyanine green (PDR ICG) as a marker of hepatic function and perfusion. Primary objective of this analysis was to investigate the impact of haemodilutional anaemia on hepatic function and perfusion by the time course of PDR ICG and liver enzymes in elective CABG surgery. Secondary objective was to define predictors of prolonged ICU treatment like decreased PDR ICG after surgery.