Pharmaceutical-grade albumin impaired drug-binding capacity in vitro 英文参考文献.docVIP

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Pharmaceutical-grade albumin impaired drug-binding capacity in vitro 英文参考文献.doc

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Pharmaceutical-grade albumin impaired drug-binding capacity in vitro 英文参考文献

BMC Clinical Pharmacology BioMedCentral Research article Open Access Pharmaceutical-grade albumin: impaired drug-binding capacity in vitro Harald Olsen1, Anders Andersen*1, Arve Nordb?2, Ulf E Kongsgaard2 and Ole P B?rmer1 Address: 1Central Laboratory, The Norwegian Radium Hospital HF, N-0310 Oslo, Norway and 2Department of Anaesthesia, The Norwegian Radium Hospital HF, N-0310 Oslo, Norway Email: Harald Olsen - har-ol@online.no; Anders Andersen* - anders.andersen@klinmed.uio.no; Arve Nordb? - arve.nordbo@siv.no; Ulf E Kongsgaard - ulf.kongsgaard@klinmed.uio.no; Ole P B?rmer - ole.bormer@labmed.uio.no * Corresponding author Published: 29 March 2004 Received: 23 December 2003 Accepted: 29 March 2004 BMC Clinical Pharmacology 2004, 4:4 This article is available from: /1472-6904/4/4 ? 2004 Olsen et al; licensee BioMed Central Ltd. This is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the articles original URL. Abstract Background: Albumin is the most abundant protein in blood plasma, and due to its ligand binding properties, serves as a circulating depot for endogenous and exogenous (e.g. drugs) compounds. Hence, the unbound drug is the pharmacologically active drug. Commercial human albumin preparations are frequently used during surgery and in critically ill patients. Recent studies have indicated that the use of pharmaceutical-grade albumin is controversial in critically ill patients. In this in vitro study we investigated the drug binding properties of pharmaceutical-grade albumins (Baxter/Immuno, Octapharma, and Pharmacia Upjohn), native human serum, and commercially available human serum albumin from Sigma Chemical Company. Methods: The binding properties of the various albumin solutions were tested in vitro by means of ultrafiltration. Naproxen, warfarin, and digitoxin were used as liga