Polymorphisms of ？174GC and ？572GC in the Interleukin 6 (IL-6) Gene and Coronary Heart Disease Risk A Meta-Analysis of 27 Research Studies 英文参考文献.docVIP

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Polymorphisms of ？174GC and ？572GC in the Interleukin 6 (IL-6) Gene and Coronary Heart Disease Risk A Meta-Analysis of 27 Research Studies 英文参考文献.doc

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Polymorphisms of ？174GC and ？572GC in the Interleukin 6 (IL-6) Gene and Coronary Heart Disease Risk A Meta-Analysis of 27 Research Studies 英文参考文献

Polymorphismsof2174G.Cand2572G.Cinthe Interleukin6(IL-6)GeneandCoronaryHeartDisease Risk:AMeta-Analysisof27ResearchStudies Guo-huaZheng1*,Hai-yingChen1,Shang-QuanXiong2 1TheCentreofEvidenceBasedMedicine,AcademyofIntegrativeMedicine,FujianUniversityofTraditionalChineseMedicine,ShangjieUniversityTown,Fuzhou,China, 2ThePeople’sHospitalofFujianProvince,Fuzhou,China Abstract Objective: Elevated serum IL-6 level is a risk factor for coronary heart disease (CHD). The 2174G.C and 2572G.C polymorphisms in the IL-6 gene have previously been shown to modulate IL-6 levels. But the association between the 2174G.C and 2572G.C polymorphisms and the risk of CHD is still unclear. A meta-analysis of all eligible studies was carriedouttoclarifytheroleofIL-6genepolymorphismsinCHD. MethodsandResults:PubMed,EMBASE,Vip,CNKIandCBM-discweresearchedforeligiblearticlesinEnglishandChinese thatwerepublishedbeforeOctober2010.27studiesinvolving11580patientswithCHDand17103controlswereincluded. Ameta-analysiswasperformedfortheincludedarticlesusingtheRevMan5.0andStata10.0softwares.Overall,the2174C allelewasnotsignificantlyassociatedwithCHDrisk(ORs=1.04,95%CI=0.98to1.10)whencomparedwiththe2174Gallele intheadditivemodel,andmeta-analysisunderothergeneticmodels(dominant,recessive,CCversusGG,andGCversusGG) alsodidnotrevealanysignificantassociation.Onthecontrary,the2572Callelewasassociatedwithadecreasedriskof CHDwhencomparedwiththe2572Gallele(ORs=0.79,95%CI=0.68to0.93).Furthermore,analysesundertherecessive model(ORs=0.69,95%=0.59to0.80)andtheallelecontrastmodel(genotypeofCCversusGG,ORs=0.49,95%=0.35to 0.70)yieldedsimilarresults.However,statisticalsignificancewasnotfoundwhenthemeta-analysiswasrestrictedtostudies focusingonEuropeanpopulations,studieswithlargesamplesize,andcohortstudiesbyusingsubgroupanalysis. Conclusions: The 2174G.C polymorphism in the IL-6 gene is not significantly associated with increased risks of CHD. However, The 2572G.C polymorphism may contribute to CHD development. Future investi