Poor prognostic clinicopathologic features correlate with VEGF expression but not with PTEN expression in squamous cell carcinoma of the larynx 英文参考文献.docVIP
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Poor prognostic clinicopathologic features correlate with VEGF expression but not with PTEN expression in squamous cell carcinoma of the larynx 英文参考文献
Sullu et al. Diagnostic Pathology 2010, 5:35
/content/5/1/35
RESEARCH
Open Access
Poor prognostic clinicopathologic features Research
correlate with VEGF expression but not with PTEN
expression in squamous cell carcinoma of the
larynx
Yurdanur Sullu*1, Seda Gun2, Sinan Atmaca3, Filiz Karagoz1 and Bedri Kandemir1
Abstract
Background: The aim of this study was to assess the relationship between expression of vascular endothelial growth
factor (VEGF) and phosphatase and tensin homolog deleted in chromosome ten (PTEN), angiogenesis and
clinicopathological parameters of squamous cell carcinoma of the larynx.
Methods: We examined immunohistochemical expression of VEGF and PTEN and CD34 for microvessel density (MVD)
in sections of formalin-fixed, paraffin embedded tissue blocks of 140 patients with squamous cell carcinoma of the
larynx. The intensity of VEGF and PTEN staining and the proportion of cells staining were scored.
Results: The tumor grade was not significantly related to PTEN expression, but it was to VEGF expression (p = 0.400; p
= 0.015, respectively). While there was no significant relationship between PTEN expression and tumor size and
cartilage invasion (p = 0.311, p = 0.128), there was a significant relationship between the severity of VEGF expression
and tumor size (p = 0.006) and lymph node metastasis (p = 0.048) but not cartilage invasion (p = 0.129). MVD was
significantly higher in high-grade tumors (p = 0.003) but had no significant relationship between MVD, lymph node
metastasis, and cartilage invasion (p = 0.815, p = 0.204). There was also no significant relationship between PTEN and
VEGF expression (p = 0.161) and between PTEN and VEGF expression and the MVD (p = 0.120 and p = 0.175,
respectively).
Conclusions: Increased VEGF expression may play an important role in the outcome of squamous cell carcinoma of
the larynx. PTEN expression was not related to VEGF expression and clinicopathological features of squamous cell
carcinoma of
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