Population Structure of a Hybrid Clonal Group of Methicillin-Resistant Staphylococcus aureus, ST239-MRSA-III 英文参考文献.docVIP
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Population Structure of a Hybrid Clonal Group of Methicillin-Resistant Staphylococcus aureus, ST239-MRSA-III 英文参考文献
PopulationStructureofaHybridClonalGroupof
Methicillin-ResistantStaphylococcusaureus,
ST239-MRSA-III
DavidaS.Smyth1¤,LindaK.McDougal2,FrodeW.Gran3,AnandManoharan4,MarkC.Enright5 ,Jae-Hoon
Song6,HerminiadeLencastre7,8,D.AshleyRobinson1¤*
1DepartmentofMicrobiologyandImmunology,NewYorkMedicalCollege,Valhalla,NewYork,UnitedStatesofAmerica,2OfficeofAntimicrobialResistance,Centersfor
DiseaseControlandPrevention,Atlanta,Georgia,UnitedStatesofAmerica,3DepartmentofMedicalMicrobiology,UniversityHospitalTrondheim,Trondheim,Norway,
4Department of Medicine Unit I and Infectious Diseases, Christian MedicalCollege, Vellore, India, 5Department ofInfectiousDisease Epidemiology, Imperial College
London,London,UnitedKingdom,6DivisionofInfectiousDiseases,SamsungMedicalCenter,SungkyunkwanUniversitySchoolofMedicine,Seoul,Korea,7Laboratoryof
MolecularGenetics,InstitutodeTecnologiaQu?′micaeBiolo′gica,UniversidadeNovadeLisboa,Oeiras,Portugal,8LaboratoryofMicrobiology,TheRockefellerUniversity,
NewYork,NewYork,UnitedStatesofAmerica
Abstract
Themethicillin-resistantStaphylococcusaureus(MRSA)clonalgroupknownasST239-MRSA-IIIisnotableforitshybridorigin
andforcausingsustainedhospitalepidemicsworldwidesincethelate1970s.Westudiedthepopulationstructureofthis
MRSAclonalgroupusingasampleof111isolatesthatwerecollectedover34yearsfrom29countries.Geneticvariationwas
assessedusingtypingmethodsandnovelascertainmentmethods,resultinginapproximately15kbofsequencefrom32
loci for all isolates. A single most parsimonious tree, free of homoplasy, partitioned 28 haplotypes into geographically-
associatedclades,includingprominentEuropean,Asian,andSouthAmericanclades.Therateofevolutionwasestimatedto
beapproximately1006fasterthanstandardestimatesforbacteria,anddatedthemostrecentcommonancestorofthese
isolatestothemid-20thcentury.AssociationswerediscoveredbetweentheST239phylogenyandtheccrBanddrulociof
themethicillinresistancegeneticelement,SCCmectypeIII,butnotwiththeaccessorycomponentsoftheelementthatare
targetedbymulti
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