Positive end-expiratory pressure at minimal respiratory elastance represents the best compromise between mechanical stress and lung aeration in oleic acid induced lung injury 英文参考文献.docVIP
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Positive end-expiratory pressure at minimal respiratory elastance represents the best compromise between mechanical stress and lung aeration in oleic acid induced lung injury 英文参考文献
Available online /content/11/4/R86
Research
Open Access
Vol 11 No 4
Positive end-expiratory pressure at minimal respiratory elastance
represents the best compromise between mechanical stress and
lung aeration in oleic acid induced lung injury
Alysson Roncally S Carvalho1, Frederico C Jandre1, Alexandre V Pino1, Fernando A Bozza2,
Jorge Salluh3, Rosana Rodrigues4, Fabio O Ascoli2 and Antonio Giannella-Neto
1Biomedical Engineering Program, COPPE, Federal University of Rio de Janeiro, Av. Horácio Macedo, CT Bloco H-327, 2030, 21941-914, Rio de
Janeiro, Brazil
2Funda??o Oswaldo Cruz, Instituto de Pesquisa Clinica Evandro Chagas e Laboratório de Imunofarmacologia, IOC, Av Brasil, 4365, Manguinhos,
21045-900 Rio de Janeiro, Brazil
3National Institute of Cancer-1, ICU, Pra?a Cruz Vermelha, 20230-130 Rio de Janeiro, Brazil
4Radiodiagnostic Service, Clementino Fraga Filho Hospital, Federal University of Rio de Janeiro, R Professor Rodolpho Paulo Rocco, 255, 21-941-
913 Rio de Janeiro, Brazil
Corresponding author: Antonio Giannella-Neto, agn@peb.ufrj.br
Received: 5 Jan 2007 Revisions requested: 20 Feb 2007 Revisions received: 3 Apr 2007 Accepted: 9 Aug 2007 Published: 9 Aug 2007
Critical Care 2007, 11:R86 (doi:10.1186/cc6093)
This article is online at: /content/11/4/R86
? 2007 Carvalho et al.; licensee BioMed Central Ltd.
This is an open access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0),
which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Introduction Protective ventilatory strategies have been applied
to prevent ventilator-induced lung injury in patients with acute
lung injury (ALI). However, adjustment of positive end-expiratory
Results Progressive reduction in PEEP from 26 cmH O to the
2
PEEP at which the minimum Ers was observed improved poorly
aerated areas, with a proportional reduction in hyperinflated
areas. Al
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