Positive end-expiratory pressure at minimal respiratory elastance represents the best compromise between mechanical stress and lung aeration in oleic acid induced lung injury 英文参考文献.docVIP

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Positive end-expiratory pressure at minimal respiratory elastance represents the best compromise between mechanical stress and lung aeration in oleic acid induced lung injury 英文参考文献.doc

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Positive end-expiratory pressure at minimal respiratory elastance represents the best compromise between mechanical stress and lung aeration in oleic acid induced lung injury 英文参考文献

Available online /content/11/4/R86 Research Open Access Vol 11 No 4 Positive end-expiratory pressure at minimal respiratory elastance represents the best compromise between mechanical stress and lung aeration in oleic acid induced lung injury Alysson Roncally S Carvalho1, Frederico C Jandre1, Alexandre V Pino1, Fernando A Bozza2, Jorge Salluh3, Rosana Rodrigues4, Fabio O Ascoli2 and Antonio Giannella-Neto 1Biomedical Engineering Program, COPPE, Federal University of Rio de Janeiro, Av. Horácio Macedo, CT Bloco H-327, 2030, 21941-914, Rio de Janeiro, Brazil 2Funda??o Oswaldo Cruz, Instituto de Pesquisa Clinica Evandro Chagas e Laboratório de Imunofarmacologia, IOC, Av Brasil, 4365, Manguinhos, 21045-900 Rio de Janeiro, Brazil 3National Institute of Cancer-1, ICU, Pra?a Cruz Vermelha, 20230-130 Rio de Janeiro, Brazil 4Radiodiagnostic Service, Clementino Fraga Filho Hospital, Federal University of Rio de Janeiro, R Professor Rodolpho Paulo Rocco, 255, 21-941- 913 Rio de Janeiro, Brazil Corresponding author: Antonio Giannella-Neto, agn@peb.ufrj.br Received: 5 Jan 2007 Revisions requested: 20 Feb 2007 Revisions received: 3 Apr 2007 Accepted: 9 Aug 2007 Published: 9 Aug 2007 Critical Care 2007, 11:R86 (doi:10.1186/cc6093) This article is online at: /content/11/4/R86 ? 2007 Carvalho et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Introduction Protective ventilatory strategies have been applied to prevent ventilator-induced lung injury in patients with acute lung injury (ALI). However, adjustment of positive end-expiratory Results Progressive reduction in PEEP from 26 cmH O to the 2 PEEP at which the minimum Ers was observed improved poorly aerated areas, with a proportional reduction in hyperinflated areas. Al