Population-Based Biochemistry, Immunologic and Hematological Reference Values for Adolescents and Young Adults in a Rural Population in Western Kenya 英文参考文献.docVIP
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Population-Based Biochemistry, Immunologic and Hematological Reference Values for Adolescents and Young Adults in a Rural Population in Western Kenya 英文参考文献
Population-BasedBiochemistry,Immunologicand
HematologicalReferenceValuesforAdolescentsand
YoungAdultsinaRuralPopulationinWesternKenya
ClementZeh1*,PauliN.Amornkul1¤a,SethInzaule2,PascaleOndoa3,BoazOyaro2,DuftonM.
Mwaengo1¤b,HildeVandenhoudt4,AnthonyGichangi1,JohnWilliamson1,TimothyThomas1¤c,KevinM.
DeCock1¤d,ClydeHart5,JohnNkengasong5,KaylaLaserson1
1U.S.CentersforDiseaseControlandPrevention(CDC-Kenya),Kisumu,Kenya,2CentreforGlobalHealthResearch,KenyaMedicalResearchInstitute/U.S.CDCResearch
andPublicHealth,Kisumu,Kenya,3DepartmentofInternalMedicine,CenterforInfectionandImmunity(CINIMA),CenterforPoverty-RelatedCommunicableDiseases
(CPCD),AcademicMedicalCenter,AmsterdamInstituteforGlobalHealthandDevelopment(AIGHD),UniversityofAmsterdam,Amsterdam,TheNetherlands,4Instituteof
TropicalMedicine(ITM),Antwerp,Belgium,5GlobalAIDSProgram,NationalCenterforHIV,ViralHepatitis,STD,andTBPrevention,U.S.CentersforDiseaseControland
Prevention,Atlanta,Georgia,UnitedStatesofAmerica
Abstract
Background:Thereisneedforlocally-derivedage-specificclinicallaboratoryreferencerangesofhealthyAfricansinsub-
Saharan Africa. Reference values from North American and European populations are being used for African subjects
despitepreviousstudiesshowingsignificantdifferences.Ouraimwastoestablishclinicallaboratoryreferencevaluesfor
Africanadolescentsandyoungadultsthatcanbeusedinclinicaltrialsandforpatientmanagement.
Methods and Findings: A panel of 298, HIV-seronegative individuals aged 13–34 years was randomly selected from
participants in two population-based cross-sectional surveys assessing HIV prevalence and other sexually transmitted
infectionsinwesternKenya.Theadolescent(,18years)-to-adults($18years)ratioandthemale-to-femaleratiowas1:1.
Medianand95%referencerangeswerecalculatedforimmunohematologicalandbiochemistryvalues.ComparedwithU.S-
derivedreferenceranges,wedetectedlowerhemoglobin(HB),hematocrit(HCT),redbloodcells(RBC),meancorpuscular
volume (MCV), neutrophil, glucose, and blood urea nitro
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