Potential Drug-Drug Interactions in Prescriptions to Patients over 45 Years of Age in Primary Care, Southern Brazil 英文参考文献.docVIP

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Potential Drug-Drug Interactions in Prescriptions to Patients over 45 Years of Age in Primary Care, Southern Brazil 英文参考文献.doc

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Potential Drug-Drug Interactions in Prescriptions to Patients over 45 Years of Age in Primary Care, Southern Brazil 英文参考文献

PotentialDrug-DrugInteractionsinPrescriptionsto Patientsover45YearsofAgeinPrimaryCare,Southern Brazil JorgeJuarezVieiraTeixeira1,4*,Ma′rciaTerezinhaLonardoniCrozatti2,CarlosAparecidodosSantos3, NicolinaSilvanaRomano-Lieber4 1DepartamentodeAna′lisesCl?′nicaseBiomedicina,CentrodeCie?nciasdaSau′de,UniversidadeEstadualdeMaringa′,Maringa′–Parana′,Brazil,2DepartamentodeCie?ncias Biolo′gicas,UniversidadeFederaldeSa?o Paulo,Diadema-Sa?o Paulo,Brazil,3DepartamentodeEstat?′stica,CentrodeCie?ncias Exatas.UniversidadeEstadualdeMaringa′, Maringa′–Parana′, Brazil,4DepartamentodePra′tica deSau′dePu′blica,FaculdadedeSau′dePu′blica,UniversidadedeSa?o Paulo.Sa?o Paulo,Brazil Abstract Background:Fewcross-sectionalstudiesinvolvingadultsandelderlypatientswithmajorDDIshavebeenconductedinthe primarycaresetting.Thestudyaimedtoinvestigatetheprevalenceofpotentialdrug-druginteractions(DDIs)inpatients treatedinprimarycare. Methodology/PrincipalFindings:Across-sectionalstudyinvolvingpatientsaged45yearsorolderwasconductedat25 Basic Health Units in the city of Maringa′ (southern Brazil) from May to December 2010. The data were collected from prescriptionsatthepharmacyofthehealthunitatthetimeofthedeliveryofmedicationtothepatient.Afterdelivery,the researchercheckedtheelectronicmedicalrecordsofthepatient.Atotalof827patientswereinvestigated(meanage:64.1; meannumberofmedications:4.4).DDIswereidentifiedintheMicromedexHdatabase.TheprevalenceofpotentialDDIsand major DDIs was 63.0% and 12.1%, respectively. In both the univariate and multivariate analyses, the number of drugs prescribedwassignificantlyassociatedwithpotentialDDIs,withanincreasingriskfromthreetofivedrugs(OR=4.74;95% CI:2.90–7.73)tosixormoredrugs(OR=23.03;95%CI:10.42–50.91).Fortydrugsaccountedfor122pairsofmajorDDIs,the mostfrequentofwhichinvolvedsimvastatin(23.8%),captopril/enalapril(16.4%)andfluoxetine(16.4%). Conclusions/Significance: This is the first large-scale study on primary care carried out in Latin America. Based on t