Prediction error variance and expected response to selection, when selection is based on the best predictor – for Gaussian and threshold characters, traits following a Poisson mixed model and survival traits 英文参考文献.docVIP

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Prediction error variance and expected response to selection, when selection is based on the best predictor – for Gaussian and threshold characters, traits following a Poisson mixed model and survival traits 英文参考文献.doc

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Prediction error variance and expected response to selection, when selection is based on the best predictor – for Gaussian and threshold characters, traits following a Poisson mixed model and survival traits 英文参考文献

Genet. Sel. Evol. 34(2002) 307–333 ?INRA, EDP Sciences, 2002 DOI: 10.1051/gse:2002010 307 Original article Predictionerrorvarianceandexpected responsetoselection,whenselection isbasedonthebestpredictor- forGaussianandthresholdcharacters, traitsfollowingaPoissonmixedmodel andsurvivaltraits IngeRiisKORSGAARD a?,AndersHolstANDERSEN b, JustJENSENa aDepartmentofAnimalBreedingandGenetics, DanishInstituteofAgriculturalSciences, P.O.Box50,8830Tjele,Denmark bDepartmentofTheoreticalStatistics,UniversityofAarhus, 8000Aarhus-C,Denmark (Received9January2001;accepted9February2002) Abstract– Inthispaper,weconsiderselectionbasedonthebestpredictorofanimaladditive geneticvaluesinGaussianlinearmixedmodels,thresholdmodels,Poissonmixedmodels,and lognormalfrailtymodelsforsurvivaldata(includingmodelswithtime-dependentcovariates withassociated?xedorrandomeffects). Inthedifferentmodels,expressionsaregiven(when these can be found - otherwise unbiased estimates are given) for prediction error variance, accuracyofselectionandexpectedresponsetoselectionontheadditivegeneticscaleandon theobservedscale. TheexpressionsgivenfornonGaussiantraitsaregeneralisationsofthe well-knownformulas forGaussian traits-andre?ect, for Poissonmixedmodels and frailty models for survival data, the hierarchal structure of the models. In general the ratio of the additivegeneticvariancetothetotalvarianceintheGaussianpartofthemodel(heritability onthenormallydistributedlevelofthemodel)orageneralisedversionofheritabilityplaysa centralroleintheseformulas. accuracy of selection / best predictor / expected response to selection / heritability / predictionerrorvariance ?Correspondenceandreprints E-mail:IngeR.Korsgaard@agrsci.dk 308 I.R.Korsgaardetal. 1.INTRODUCTION Forbinarythresholdcharactersheritabilityhasbeende?nedontheunder- lyingscale(liabilityscale)andontheobservedscale(outwardscale)(see[4] and[14]),andthede?nitionsweregeneralisedtoorderedcategoricaltraitsby Gianola[9].ForPoissonmixedmodelsade?nitionofheritab