Probiotics for severe trauma patients 英文参考文献.docVIP

Rijkers Critical Care 2011,15:1022 /content/15/6/1022 COMMENTARY Probiotics for severe trauma patients Ger T Rijkers * 1,2 See related research by Tan et al., /content/15/6/R290 been published. With regard to the prevention of ventilator-associated pneumonia in critically ill patients admitted to the ICU, Morrow and colleagues reported a positive e? ect [7], while in the study of Barraud and colleagues no e? ect was found in this respect [8]. Tan and colleagues [1] now present the results of a pilot study on the immunomodulatory as well as clinical e? ects of a multispecies probiotic preparation in patients with severe Abstract Probiotics are live micro-organisms with a health promoting e?ect. Because of their immunomodulating capacity as well as improvement of gut barrier function, probiotics have the capacity to prevent infectious complications in a variety of clinical settings. Now selected probiotics show potential for improving the clinical outcome of severe trauma patients. brain trauma eir study is important because it is the ? rst one in this patient category that includes biomarkers of the immune system. Trauma itself is known to cause a e present issue of Critical Care features a publication depression of the Thelper 1 ( 1) cytokines IL-12 p70, by Min Tan and colleagues from the A? liated Hospital of and interferon-γ [9]. IL-12 is the maj 1 driving North Sichuan Medical College in China on the use of cytokine while interferon-γ potentiates cellular immunity probiotics in severe traumatic brain injury patients [1]. as well as macrophage function. During the ? rst week no Critically ill trauma patients have many reasons to di? erences in cytokine levels were found between the develop infectious complications when admitted to the intervention and control groups, but afterwards, IL-12 ICU. Trauma causes a massive