Prognostic Significance of Subtype Classification for Short- and Long-Term Survival in Breast Cancer Survival Time Holds the Key 英文参考文献.docVIP

Perspective PrognosticSignificanceofSubtypeClassificationfor Short-andLong-TermSurvivalinBreastCancer:Survival TimeHoldstheKey StefanAmbs* LaboratoryofHumanCarcinogenesis(LHC),CenterforCancerResearch(CCR),NationalCancerInstitute(NCI),Bethesda,Maryland,UnitedStatesofAmerica ‘‘Westilllacktheabilityto accuratelypredictsurvival amongbreastcancerpatients withearly-stagedisease’’ teristics [7,8]. They include two estrogen receptor (ER)-positive subtypes, termed luminal A and B, and three ER-negative subtypes, termed basal-like, HER2-posi- tive, and normal breast-like tumors. Lu- minal tumors develop more frequently than the other subtypes and share many featureswithluminalepithelialcellslining the mammary ducts, but tumors in the luminal B subgroup also aberrantly over- express the HER2 receptor or prolifera- tion marker genes that distinguish them from the HER2-negative luminal A tu- mors.Basal-likebreastcancerhassimilar- ities with normal breast basal epithelial cellsandiscommonlyidentifiedbyalack ofERandHER2receptorexpressionand bytheexpressionofeithercytokeratin5/6 LinkedResearchArticle This Perspective discusses the fol- lowingnewstudypublishedinPLoS Medicine: Advancesinhormonetherapyandcom- bination chemotherapy have led to signifi- cant declines in disease recurrence and mortalityduetobreastcancer[1,2].How- ever, the burden of developing a deadly diseaseremainsunequal.Adiseasediagnosis at age 50 or younger is still more likely to have a fatal outcome than the same diagnosis at an older age. Moreover, African-American women and women di- agnosed with estrogen, progesterone, and HER2 receptor–negative disease (termed triple-negative breast cancer) continue to experienceanexcessivemortalityandhave not benefited from the advances in breast cancer therapy as much as other patient groups[3,4].Currently,about10%ofbreast cancerpatientswillsuccumbtothedisease withinthefirst5yearsfollowingtheinitial diagnosis[5],despitemanybeingdiagnosed withanearly-stagedisease.Therel