Protease inhibitor associated mutations compromise the efficacy of therapy in human immunodeficiency virus – 1 (HIV-1) infected pediatric patients a cross-sectional study 英文参考文献.docVIP

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Protease inhibitor associated mutations compromise the efficacy of therapy in human immunodeficiency virus – 1 (HIV-1) infected pediatric patients a cross-sectional study 英文参考文献.doc

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Protease inhibitor associated mutations compromise the efficacy of therapy in human immunodeficiency virus – 1 (HIV-1) infected pediatric patients a cross-sectional study 英文参考文献

AIDS Research and Therapy BioMedCentral Research Open Access Protease inhibitor associated mutations compromise the efficacy of therapy in human immunodeficiency virus – 1 (HIV-1) infected pediatric patients: a cross-sectional study Amisha Malhotra*1, Sunanda Gaur1, Patricia Whitley-Williams1, Caitlin Loomis2 and Anna Petrova1 Address: 1Department of Pediatrics, Division of Infectious Disease, University of Medicine and Dentistry of New Jersey (UMDNJ) – Robert Wood Johnson Medical School, New Brunswick, New Jersey 08903, USA and 2Princeton University, Princeton, New Jersey-08542, USA Email: Amisha Malhotra* - malhotam@; Sunanda Gaur - gaursu@; Patricia Whitley-Williams - whitlepn@; Caitlin Loomis - caitlin.loomis@; Anna Petrova - petroran@ * Corresponding author Published: 9 July 2007 Received: 30 October 2006 Accepted: 9 July 2007 AIDS Research and Therapy 2007, 4:15 doi:10.1186/1742-6405-4-15 This article is available from: /content/4/1/15 ? 2007 Malhotra et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Background: Although the introduction of combined therapy with reverse transcriptase and protease inhibitors has resulted in considerable decrease in HIV related mortality; it has also induced the development of multiple drug-resistant HIV-1 variants. The few studies on HIV-1 mutagenesis in HIV infected children have not evaluated the impact of HIV-1 mutations on the clinical, virological and immunological presentation of HIV disease that is fundamental to optimizing the treatment regimens for these patients. Results: A cross sectional study was conducted to evaluate the impact of treatment regimens and resistance mutation patterns on the clinical, virological, and immunological present