Promising Therapeutics with Natural Bioactive Compounds for Improving Learning and Memory — A Review of Randomized Trials 英文参考文献.docVIP

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Promising Therapeutics with Natural Bioactive Compounds for Improving Learning and Memory — A Review of Randomized Trials 英文参考文献.doc

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Promising Therapeutics with Natural Bioactive Compounds for Improving Learning and Memory — A Review of Randomized Trials 英文参考文献

Molecules 2012, 17, 10503-10539; doi:10.3390/molecules170910503 OPEN ACCESS molecules ISSN 1420-3049 /journal/molecules Review Promising Therapeutics with Natural Bioactive Compounds for Improving Learning and Memory — A Review of Randomized Trials Hemant Kumar 1, Sandeep Vasant More 1, Sang-Don Han 2, Jin-Yong Choi 2 and Dong-Kug Choi 1,* 1 Department of Biotechnology, Konkuk University, Chungju 380-701, Korea 2 Department of Neurology, School of Medicine, Konkuk University, Chungju 380-704, Korea * Author to whom correspondence should be addressed; E-Mail: choidk@kku.ac.kr; Tel.: +82-43-840-3610; Fax: +82-43-840-3872. Received: 31 July 2012; in revised form: 6 August 2012 / Accepted: 27 August 2012 / Published: 3 September 2012 Abstract: Cognitive disorders can be associated with brain trauma, neurodegenerative disease or as a part of physiological aging. Aging in humans is generally associated with deterioration of cognitive performance and, in particular, learning and memory. Different therapeutic approaches are available to treat cognitive impairment during physiological aging and neurodegenerative or psychiatric disorders. Traditional herbal medicine and numerous plants, either directly as supplements or indirectly in the form of food, improve brain functions including memory and attention. More than a hundred herbal medicinal plants have been traditionally used for learning and memory improvement, but only a few have been tested in randomized clinical trials. Here, we will enumerate those medicinal plants that show positive effects on various cognitive functions in learning and memory clinical trials. Moreover, besides natural products that show promising effects in clinical trials, we briefly discuss medicinal plants that have promising experimental data or initial clinical data and might have potential to reach a clinical trial in the near future. Keywords: learning and memory; c