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Protein Aggregation Profile of the Bacterial Cytosol 英文参考文献
ProteinAggregationProfileoftheBacterialCytosol
NataliaS.deGroot,SalvadorVentura*
DepartamentdeBioqu?′micaiBiologiaMolecular,UniversitatAuto`nomadeBarcelona,Barcelona,Spain
Abstract
Background:Proteinmisfoldingisusuallydeleteriousforthecell,eitherasaconsequenceofthelossofproteinfunctionor
thebuildupofinsolubleandtoxicaggregates.Theaggregationbehaviorofagivenpolypeptideisstronglyinfluencedby
theintrinsicpropertiesencodedinitssequence.Thishasallowedthedevelopmentofeffectivecomputationalmethodsto
predictproteinaggregationpropensity.
Methodology/PrincipalFindings:Here,weusetheAGGRESCANalgorithmtoapproximatetheaggregationprofileofan
experimental cytosolic Escherichia coli proteome. The analysis indicates that the aggregation propensity of bacterial
proteinsisassociatedwiththeirlength,conformation,location,function,andabundance.Thedataareconsistentwiththe
predictionsofotheralgorithmsondifferenttheoreticalproteomes.
Conclusions/Significance: Overall, the study suggests that the avoidance of protein aggregation in functional
environments acts as a strong evolutionary constraint on polypeptide sequences in both prokaryotic and eukaryotic
organisms.
Citation:deGrootNS,VenturaS(2010)ProteinAggregationProfileoftheBacterialCytosol.PLoSONE5(2):e9383.doi:10.1371/journal.pone.0009383
Editor:HilalLashuel,SwissFederalInstituteofTechnologyLausanne,Switzerland
ReceivedOctober25,2009;AcceptedJanuary30,2010;PublishedFebruary25,2010
Copyright:?2010deGroot,Ventura.Thisisanopen-accessarticledistributedunderthetermsoftheCreativeCommonsAttributionLicense,whichpermits
unrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalauthorandsourcearecredited.
Funding:ThisworkwassupportedbygrantsBIO2007-68046-C02-02fromMinisteriodeCienciayInnovacio′n(Spain)and2009-SGR-760fromAge`ncia deGestio′
d’AjutsUniversitarisideRecerca(GeneralitatdeCatalunya).NSdGwasbeneficiaryofaFormacio′ndelPersonalInvestigadorfellowshipawardedbytheMinisterio
deCienciayInnovacio′n(Spain).Thefundersha
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