Protein C a potential biomarker in severe sepsis and a possible tool for monitoring treatment with drotrecogin alfa (activated) 英文参考文献.docVIP

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Protein C a potential biomarker in severe sepsis and a possible tool for monitoring treatment with drotrecogin alfa (activated) 英文参考文献.doc

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Protein C a potential biomarker in severe sepsis and a possible tool for monitoring treatment with drotrecogin alfa (activated) 英文参考文献

Available online /content/12/2/R45 Research Open Access Vol 12 No 2 Protein C: a potential biomarker in severe sepsis and a possible tool for monitoring treatment with drotrecogin alfa (activated) Andrew F Shorr1, David R Nelson2, Duncan LA Wyncoll3, Konrad Reinhart4, Frank Brunkhorst4, George Matthew Vail2 and Jonathan Janes2 1Department of Medicine, Section of Pulmonary and Critical Care Medicine, Washington Hospital Center, Irving Street, Washington, District of Columbia 20010, USA 2Lilly Research Laboratories, Eli Lilly and Company, 520 S. Meridian, Indianapolis, Indiana 46285, USA 3Department of Critical Care, Guys and St Thomas NHS Foundation Trust, Lambeth Palace Road, London SE1 7EH, UK 4Department of Anesthesiology and Intensive Care, Friedrich Schiller University, Erlanger Allee, Jena 07740, Germany Corresponding author: Andrew F Shorr, afshorr@ Received: 19 Nov 2007 Revisions requested: 9 Jan 2008 Revisions received: 13 Feb 2008 Published: 4 Apr 2008 Critical Care 2008, 12:R45 (doi:10.1186/cc6854) This article is online at: /content/12/2/R45 ? 2008 Shorr et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Introduction Drotrecogin alfa (activated; DrotAA) treatment, a 96-hour infusion, reduces 28-day mortality in severe sepsis to approximately 25%. The question remains whether a longer infusion or higher dose could increase rate of survival. The goal of this study was to identify a dependable, sensitive measure with which to monitor disease progression and response in patients during DrotAA treatment. Results Protein C was the only variable that correlated with outcome across all analyses. Using placebo data, a baseline protein C under 40% was established as a useful predictor o