Protein Complexes are Central in the Yeast Genetic Landscape 英文参考文献.docVIP

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Protein Complexes are Central in the Yeast Genetic Landscape 英文参考文献.doc

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Protein Complexes are Central in the Yeast Genetic Landscape 英文参考文献

ProteinComplexesareCentralintheYeastGenetic Landscape MagaliMichaut1,2,AnastasiaBaryshnikova1,2,3,MichaelCostanzo1,2,3,ChadL.Myers5,BrendaJ. Andrews1,2,3,CharlesBoone1,2,3,GaryD.Bader1,2,3,4 * 1TheDonnelly Centre,University ofToronto,Toronto,Ontario,Canada,2BantingandBestDepartment ofMedicalResearch, University ofToronto,Toronto,Ontario, Canada, 3Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada, 4Department of Computer Science, University of Toronto, Toronto, Ontario,Canada,5DepartmentofComputerScienceandEngineering,UniversityofMinnesota,Minneapolis,Minnesota,UnitedStatesofAmerica Abstract Ifperturbingtwogenestogetherhasastrongerorweakereffectthanexpected,theyaresaidtogeneticallyinteract.Genetic interactions are important because they help map gene function, and functionally related genes have similar genetic interaction patterns. Mapping quantitative (positive and negative) genetic interactions on a global scale has recently becomepossible.Thisdataclearlyshowsgroupsofgenesconnectedbypredominantlypositiveornegativeinteractions, termed monochromatic groups. These groups often correspond to functional modules, like biological processes or complexes,orconnectionsbetweenmodules.Howeveritisnotyetknownhowthesepatternsgloballyrelatetoknown functional modules. Here we systematically study the monochromatic nature of known biological processes using the largestquantitativegeneticinteractiondatasetavailable,whichincludesfitnessmeasurementsfor,5.4milliongenepairs in the yeast Saccharomyces cerevisiae. We find that only 10% of biological processes, as defined by Gene Ontology annotations,andlessthan1%ofinter-processconnectionsaremonochromatic.Further,weshowthatproteincomplexes areresponsibleforasurprisinglylargefractionofthesepatterns.Thissuggeststhatcomplexesplayacentralroleinshaping the monochromatic landscape of biological processes. Altogether this work shows that both positive and negative monochromaticpatternsarefoundinknownbiologi