Quantitative Characteristics of Gene Regulation by Small RNA 英文参考文献.docVIP

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Quantitative Characteristics of Gene Regulation by Small RNA 英文参考文献.doc

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Quantitative Characteristics of Gene Regulation by Small RNA 英文参考文献

o PL SBIOLOGY QuantitativeCharacteristicsofGeneRegulation bySmallRNA Erel Levine1,Zhongge Zhang2,Thomas Kuhlman1,Terence Hwa1* 1CenterforTheoreticalBiologicalPhysics,UniversityofCaliforniaSanDiego,LaJolla,California,UnitedStatesofAmerica,2DivisionofBiologicalSciences,Universityof CaliforniaSanDiego,LaJolla,California,UnitedStatesofAmerica An increasing number of small RNAs (sRNAs) have been shown to regulate critical pathways in prokaryotes and eukaryotes. In bacteria, regulation by trans-encoded sRNAs is predominantly found in the coordination of intricate stressresponses.ThemechanismsbywhichsRNAsmodulateexpressionofitstargetsarediverse.Incommontomost is thepossibility that interference with the translation of mRNA targets mayalso alterthe abundance of functional sRNAs. Aiming to understand the unique role played by sRNAs in gene regulation, we studied examples from two distinctclassesofbacterialsRNAsinEscherichiacoliusingaquantitativeapproachcombiningexperimentandtheory. OurresultsdemonstratethatsRNAprovidesanovelmodeofgeneregulation,withcharacteristicsdistinctfromthose of protein-mediated gene regulation. These include a threshold-linear response with a tunable threshold, a robust noiseresistancecharacteristic,andabuilt-incapabilityforhierarchicalcross-talk.Knowledgeofthesespecialfeatures of sRNA-mediated regulation may be crucial toward understanding the subtle functions that sRNAs can play in coordinating various stress-relief pathways. Our results mayalso help guide thedesign ofsynthetic genetic circuits thathavepropertiesdifficulttoattainwithproteinregulatorsalone. Citation:LevineE,ZhangZ,KuhlmanT,HwaT(2007)QuantitativecharacteristicsofgeneregulationbysmallRNA.PLoSBiol5(9):e229.doi:10.1371/journal.pbio.0050229 ofmultipletargetgenes,andarethemselvesregulatedbyone ormoretranscriptionfactors.Theyhavebeenimplicatedin Introduction SmallnoncodingRNAs(sRNAs)havebeendemonstratedin recent years to play central regulatory roles in prokaryotes and eukaryotes [1–4]. O